文献类型：期刊文献

英文题名：Association of long-term use of low-dose aspirin with Helicobacter pylori infection and effect on recurrence rate

作者：Zhou, Yun[1,2];Qiao, Yuqin[2];Zhao, Li[3];Zhang, Xiaodong[4];Yang, Shengyi[5];Bai, Lumucao[2];Liu, Shixiong[1,2]

第一作者：Zhou, Yun

通信作者：Liu, SX[1];Liu, SX[2]

机构：[1]Lanzhou Univ, Dept Geriatr, Hosp 1, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Med Ultrasound, Affiliated Hosp, Lanzhou 730020, Peoples R China;[4]ZhangYe Second Peoples Hosp, Intens Care Unit, Zhangye 734000, Peoples R China;[5]Tianshui Combine Tradit Chinese & Western Med Hosp, Intens Care Unit, Tianshui 741020, Peoples R China

第一机构：Lanzhou Univ, Dept Geriatr, Hosp 1, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Dept Geriatr, Hosp 1, Lanzhou 730000, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China.

年份：2024

卷号：14

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001354536300088)】；

基金：This work was supported by Hospital fund of The First Hospital of Lanzhou University (ldyyyyn2023-46); Science and technology Project of Gansu Province (Key Research and Development Program, 21YF5FA120);Gansu Province Health Industry Research Project (GSWSKY2020-12).

语种：英文

摘要：To investigate the relationship between long-term use of low-dose aspirin and Helicobacter pylori (HP) infection, and its effect on eradication and recurrence of HP. According to the results of C14-Urea Breath Test (C14-UBT), 3256 patients with cardiovascular and cerebrovascular diseases from March 2019 to December 2020, were divided into HP infection group and non-infection group. Univariate and multivariate was used to investigate the relationship between Low-dose aspirin use and HP infection. 859 patients with hypertension combined with HP infection were divided into aspirin group, non-aspirin group and control group, the eradication rate after 2 weeks of bismuth-containing quadruple drug treatment and the recurrence rate after 1,3 year were compared. The overall infection rate of HP was 53.3%. The results of univariate analysis showed that the infection rate of female, age, BMI, LDL-C, FBG of HP infected group was higher than non-infection. The infection rate of patients who took low-dose aspirin was higher than no-aspirin [56.6% vs. 51.3%, chi(2) = 8.548, P = 0.003]. Multivariate Logistic regression analysis showed that long-term aspirin use still increased the risk of infection (OR = 1.433, 95% CI 1.196-1.947, P < 0.001). The Per-Protocol analysis showed that the overall eradication rate was 87.6%, and among the eradication rates of aspirin group, non-aspirin group and control group were not statistically significantly (87.8%, 88.5%, and 86.6%, respectively), The Intention-To-Treat analysis showed that the overall eradication rate was 84.3%, and the eradication rates among the three groups were not statistically significantly. The overall 1-year recurrence rate was 1.3%, and the recurrence rates of the three groups were no statistical significance. The overall 3-years recurrence rate was 3.1%, and the recurrence rate of aspirin group was higher than non-aspirin group and control group (5.30%, 1.90% and 1.70%, respectively, chi(2) = 6.118, P < 0.05). The main adverse reactions in the first month of eradication treatment were constipation and mild nausea, and there was no statistical significance between the three groups. Long-term use of low-dose aspirin increases the risk of HP infection and the recurrence rate in 3 years after eradication. It is suggested that HP should be tested and eradicated regularly in long-term users.