文献类型：期刊文献

英文题名：Case Report: Management of cervical intramedullary spinal cord metastasis from NSCLC with a literature review

作者：Liu, Hua[1,2];Chen, Long[1,2];Li, Feng[3];Zhang, Mingjiu[1,2];Zhang, Tao[1];Li, Songkai[1]

第一作者：Liu, Hua;刘卉;刘晖;刘宏

通信作者：Li, SK[1]

机构：[1]940th Hosp Joint Logist Support Force Chinese Peop, Dept Spinal Surg, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Sch 1, Lanzhou, Gansu, Peoples R China;[3]943rd Hosp Joint Logist Support Force Chinese Peop, Dept Orthoped, Wuwei, Gansu, Peoples R China

第一机构：940th Hosp Joint Logist Support Force Chinese Peop, Dept Spinal Surg, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force Chinese Peop, Dept Spinal Surg, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：13

外文期刊名：FRONTIERS IN SURGERY

收录：;Scopus(收录号：2-s2.0-105032409967);WOS:【SCI-EXPANDED(收录号:WOS:001710485600001)】；

语种：英文

外文关键词：case report; cervical spine; intramedullary spinal cord metastases (ISCM); literature review; multimodal therapy; non-small cell lung cancer (NSCLC); survival

摘要：Background Intramedullary spinal cord metastases (ISCM) from non-small cell lung cancer (NSCLC) are rare and carry a grave prognosis. Cervical segment involvement is exceptionally uncommon, and its distinct clinicopathological profile is not well characterized.Methods We present the case of a 72-year-old male with a history of NSCLC who developed acute quadriparesis and sphincter dysfunction. Cervical magnetic resonance imaging (MRI) revealed a C7 intramedullary mass. The patient underwent C6-T1 laminectomy with microsurgical gross-total resection. Histopathology confirmed metastatic lung adenocarcinoma. We supplemented this case with a systematic literature review of NSCLC-derived ISCM cases to summarize demographic, clinical, and therapeutic outcomes.Results Histopathology confirmed metastatic lung adenocarcinoma. Postoperatively, the patient's neurological function improved. Although local recurrence was detected at 11 months and treated with salvage radiotherapy, the patient nevertheless maintained ambulatory function and was alive at the 18-month follow-up. Our literature review of 68 cases with complete data identified a male predominance (4.2:1 ratio) and a mean age of 58.1 years. The cervical spine was the most commonly involved segment (47.1%). Analysis of treatment modalities revealed that multimodal therapy, particularly the combination of surgery and chemotherapy (potentially incorporating modern agents such as immune checkpoint inhibitors), was associated with improved survival, with a mean overall survival of 15.0 months in this subgroup. This paradigm, centered around maximal safe resection, successfully achieved long-term functional preservation and survival.Conclusion Cervical ISCM from NSCLC represents one of the most challenging complications in spinal oncology. This case, supported by our literature review, provides a surgical-led, multimodal management template for spine surgeons, demonstrating that aggressive yet strategic intervention can achieve favorable long-term neurological and survival outcomes.