文献类型：期刊文献

英文题名：Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)

作者：Shang, Ruofeng[1];Liang, Jianping[1];Yi, Yunpeng[1];Liu, Yu[1];Wang, Jiatu[2]

第一作者：Shang, Ruofeng

通信作者：Wang, JT[1]

机构：[1]CAAS, Key Lab New Anim Drug Project Gansu Prov, Key Lab Vet Pharmaceut Dev, Minist Agr,Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China

第一机构：CAAS, Key Lab New Anim Drug Project Gansu Prov, Key Lab Vet Pharmaceut Dev, Minist Agr,Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2015

卷号：20

期号：9

起止页码：16127

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-84942645426);WOS:【SCI-EXPANDED(收录号:WOS:000362505300039)】；

基金：This work was supported by grants from Basic Scientific Research Funds in Central Agricultural Scientific Research Institutions (No. 1610322014003) and The Agricultural Science and Technology Innovation Program (CAAS-ASTIP-2014-LIHPS-04).

语种：英文

外文关键词：platensimycin; platencin; drug resistance; antibacterial activities; synthesis; analogues

摘要：Platensimycin and platencin were successively discovered from the strain Streptomyces platensis through systematic screening. These natural products have been defined as promising agents for fighting multidrug resistance in bacteria by targeting type II fatty acid synthesis with slightly different mechanisms. Bioactivity studies have shown that platensimycin and platencin offer great potential to inhibit many resistant bacteria with no cross-resistance or toxicity observed in vivo. This review summarizes the general information on platensimycin and platencin, including antibacterial and self-resistant mechanisms. Furthermore, the total synthesis pathways of platensimycin and platencin and their analogues from recent studies are presented.