文献类型：期刊文献

英文题名：In vitro drug release and antibacterial activity evaluation of silk fibroin coated vancomycin hydrochloride loaded poly (lactic-co-glycolic acid) (PLGA) sustained release microspheres

作者：Li, Shengtang[1,2];Shi, Xuewen[3];Xu, Bo[1,2];Wang, Jian[4];Li, Peng[4];Wang, Xin[3];Lou, Jinpeng[3];Li, Ziyao[1,2];Yang, Chengwei[2];Li, Songkai[2];Zhen, Ping[2]

第一作者：Li, Shengtang

通信作者：Li, ST[1];Zhen, P[1]

机构：[1]Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China;[2]940th Hosp, Peoples Liberat Army China, Joint Logist Support Force, Lanzhou 730050, Gansu, Peoples R China;[3]Ningxia Med Univ, Yinchuan, Ningxia, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China

通信机构：[1]corresponding author), 940th Hosp, Peoples Liberat Army China, Joint Logist Support Force, Lanzhou 730050, Gansu, Peoples R China.

年份：2022

卷号：36

期号：9

起止页码：1676

外文期刊名：JOURNAL OF BIOMATERIALS APPLICATIONS

收录：;EI(收录号：20220311482550);Scopus(收录号：2-s2.0-85122854859);WOS:【SCI-EXPANDED(收录号:WOS:000748549200001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Military Medical Science and Technology Youth Nurturing Program (grant number 20QNPY071).

语种：英文

外文关键词：silk fibroin; PLGA; vancomycin hydrochloride; drug sustained release; antibacterial activity

摘要：Currently, the treatment of osteomyelitis poses a great challenge to clinical orthopedics. The use of biodegradable materials combined with antibiotics provides a completely new option for the treatment of osteomyelitis. In this study, vancomycin hydrochloride (VANCO) loaded poly (lactic-co-glycolic acid) (PLGA) microspheres were prepared by a double emulsion solvent evaporation method, and the in vitro drug release behaviors of the drug loaded microspheres were explored after coating with different concentrations of silk fibroin (SF). Drug loading, encapsulation efficiency, Scanning electron microscopy, particle size analysis, Fourier transform infrared spectroscopy, hydrophilicity, in vitro drug release, and in vitro antibacterial activity were evaluated. The results showed that the drug loading of vancomycin loaded PLGA microspheres was (24.11 +/- 1.72)%, and the encapsulation efficiency was (48.21 +/- 3.44)%. The in vitro drug release indicated that the drug loaded microspheres showed an obvious initial burst release, and the drug loaded microspheres coated with SF could alleviate the initial burst release in varying degrees. It also can reduce the amount of cumulative drug release, and the effect of microspheres coated with 0.1% concentration of SF is the best. The time of in vitro drug release in different groups of drug loaded microspheres can be up to 28 days. The microspheres coated with (0.1%SF) or without (0%SF) SF showed a cumulative release of (82.50 +/- 3.51)% and (67.70 +/- 3.81)%,respectively. Therefore, the surface coating with SF of vancomycin loaded microspheres can alleviate the initial burst release, reduce the cumulative drug release, potentially prolong the drug action time, and improve the anti-infection effect.