文献类型：期刊文献

英文题名：Caffeic Acid Alleviates Chronic Sleep Deprivation-Induced Intestinal Damage by the IMD in

作者：Yang, Dan[1];Xiu, Minghui[2];Jiang, Xiaolin[1];Kang, Qian[1];Fu, Jinyu[1];Zhou, Shihong[2];Liu, Yongqi[2];He, Jianzheng[1,2,3]

第一作者：Yang, Dan

通信作者：He, JZ[1];He, JZ[2];He, JZ[3]

机构：[1]Gansu Univ Chinese Med, Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Peoples R China.|[107359c91a78c5fd2e803]甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）;[10735]甘肃中医药大学;[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;

年份：2025

卷号：18

起止页码：3485

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001472556200001)】；

基金：Acknowledgments We thank the Bloomington Stock Center (BSC) for providing the fly stocks. The authors appreciate the financial support received from the National Natural Science Foundation of China (No. 82104562) , Gansu Natural Science Foundation (No. 23JRRA1202) , Gansu Higher Education Industry Support Plan Project (No. 2025cYzc-47) , Foundation of Key Laboratory of Dunhuang Medicine and Translational Education Ministry of Education (No. DHYX24-02) .

语种：英文

外文关键词：thermogenetic CSD; intestine; Immune signaling; polyphenolic compounds; Drosophila melanogaster

摘要：Background: Sleep is vital for maintaining the health of the organism. Chronic sleep deprivation (CSD) is a key contributor to significant health risks, including the induction of gastrointestinal disorders. However, the mechanism of CSD caused intestinal damage remains unclear. Methods: Drosophila melanogaster as an in vivo model was used to investigate the mechanism of CSD-induced intestinal injury, as well as the ameliorative effect of caffeic acid. Results: CSD resulted in reduced survival and severely affected intestinal homeostasis in flies, as evidenced by disruption of intestinal acid-base homeostasis, increased feeding, increased intestinal permeability and shortened intestinal length. Meanwhile, the expressions of the immune deficiency (IMD) pathway-related genes PGRP-SB1, Dpt, AttA, AttB and Mtk were significantly up-regulated in the intestine of CSD flies. On the other hand, Caffeic acid supplementation restored intestinal acid-base homeostasis and intake, while improving intestinal barrier permeability and intestinal length, and effectively reducing intestinal damage. In addition, administration of caffeic acid decreased the expressions of PGRP-SB1, Dpt, AttA and Mtk genes in the CSD flies gut. Discussion: These results suggested that CSD could disrupt gut homeostasis in adult flies by overactivating the IMD pathway, while Caffeic acid has an obvious protective role on the gut homeostasis.