文献类型：期刊文献

中文题名：外泌体影响急性胰腺炎多脏器损伤的研究进展

英文题名：Research Progress on Effects of Exosomes on Multiple Organ Injury in Acute Pancreatitis

作者：连源[1];白敏[1];汪湛东[1];张钰[1];王琼[1];汪永锋[1,2];郭超[1,3];宋冰[1,3];张延英[1,3]

第一作者：连源

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃医学院,平凉744000;[3]甘肃省实验动物行业技术中心,兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：46

期号：8

起止页码：1580

中文期刊名：中国细胞生物学学报

外文期刊名：Chinese Journal of Cell Biology

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；PubMed;

基金：国家自然科学基金(批准号:82360898、82160871);甘肃省自然科学基金(批准号:22JR5RA591);甘肃省中医药管理局重点项目(批准号:GZKZ-2021-10)资助的课题。

语种：中文

中文关键词：外泌体;急性胰腺炎;多脏器损伤;发病机制

外文关键词：exosome;acute pancreatitis;multiple organ injury;pathogenesis

摘要：急性胰腺炎(acute pancreatitis,AP)是临床常见的急腹症,以胰腺为发病中心,随着病程的发展可诱导机体产生全身性炎症反应,累及肺、肠、肝脏及肾脏等身体多个器官。外泌体是由细胞产生的携带多种活性物质的细胞外囊泡,可充当细胞间信息交流的介质。近年来研究发现临床AP患者血浆外泌体存在显著特异性改变,相关基础研究进一步揭示了外泌体在AP多脏器损伤中的关键作用。该文就外泌体的生物发生过程及其在AP多脏器损伤中的作用机制进行综述,以进一步明确其影响AP多脏器损伤的具体机制,为AP临床治疗提供新的方向。
AP(acute pancreatitis) is a clinically common acute abdominal disorder centered on the pancreas that over the course of the disease can induce systemic inflammation that affects multiple organs of the body,including the lungs,intestines,liver,and kidneys.Exosomes are extracellular vesicles produced by cells that carry a variety of active substances and can act as mediators for information exchange between cells.Recent studies have found significant specific changes in plasma exosomes in patients with clinical AP,and relevant basic studies have further revealed the key role of exosomes in AP multiple organ injury.In this paper,the biogenetic process of exosomes and the mechanism of action in AP multiple organ injury were reviewed,so as to further clarify the specific mechanism of exosomes affecting AP multiple organ injury,and provided a new direction for clinical treatment of AP.