文献类型：期刊文献

英文题名：Application of Smart Hydrogels in Diabetic Wound Management: Microenvironment-Responsive Strategies and Clinical Translation Challenges

作者：Li, Chengru[1];Wang, Kechao[2];Xia, Shu[5,6];Hu, Pengfei[1];Liu, Huihui[1];Liu, Chong[3];Wang, Sijiong[4];Xian, Mingjiang[1];Song, Hao[7]

第一作者：Li, Chengru

通信作者：Xia, S[1];Xia, S[2];Song, H[3]

机构：[1]Gansu Med Coll, 192 Liuhu Rd, Pingliang 744000, Gansu, Peoples R China;[2]Huazhong Univ Sci & Technol, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Peoples R China;[3]Cent South Univ, Xiangya Hosp, Bioinformat Ctr, Natl Clin Res Ctr Geriatr Disorders,Dept Geriatr, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China;[4]Gansu Univ Chinese Med, Clin Med Coll 1, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[5]Duke Kunshan Univ, Med Phys Grad Program, 8 Duke Ave, Kunshan 215316, Peoples R China;[6]Duke Univ, Grad Sch, 2138 Campus Dr, Durham, NC 27708 USA;[7]Lanzhou Univ Second Hosp, Dept Gen Surg, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China

第一机构：Gansu Med Coll, 192 Liuhu Rd, Pingliang 744000, Gansu, Peoples R China

通信机构：[1]corresponding author), Duke Kunshan Univ, Med Phys Grad Program, 8 Duke Ave, Kunshan 215316, Peoples R China;[2]corresponding author), Duke Univ, Grad Sch, 2138 Campus Dr, Durham, NC 27708 USA;[3]corresponding author), Lanzhou Univ Second Hosp, Dept Gen Surg, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.

年份：2026

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;Scopus(收录号：2-s2.0-105046861481);WOS:【SCI-EXPANDED(收录号:WOS:001817340400001)】；

语种：英文

外文关键词：smart hydrogels; diabetic foot ulcers; microenvironment remodeling; theranostics; spatiotemporal release; AI-driven design; clinical translation

摘要：Diabetic wounds (DWs), characterized by pathological features of healing stagnation and limited regeneration, pose significant clinical challenges in chronic wound management and contribute to substantial consumption of healthcare resources. Although current clinical interventions heavily rely on debridement, offloading, and traditional wound dressings, their therapeutic efficacy often falls short of expectations due to limitations in providing only a physical barrier function. Furthermore, the pathogenesis of DWs involves a complex interplay of multiple pathological factors, including peripheral neuropathy, peripheral arterial disease, and foot infections, which further complicates wound management. In recent years, hydrogels have demonstrated significant potential in the biomedical field of DW management due to their biological versatility, tunable physicochemical properties, and excellent hydrophilicity. By loading specific therapeutic agents, hydrogels can achieve on-demand drug release tailored to the unique physiological microenvironment of DWs and optimize the microenvironment across different stages of wound healing. This study systematically evaluates smart hydrogel-based integrated diagnosis and therapy strategies by analyzing pathological characteristics and clinical limitations of DWs (particularly diabetic foot ulcers), aiming to provide references for developing clinically translatable dressing systems and establish theoretical frameworks with practical guidelines for next-generation intelligent dressings incorporating AI-driven data and clinical stability.