文献类型：期刊文献

中文题名：体素内不相干运动扩散加权成像对正常腰椎间盘扫描的可重复性研究

英文题名：Reproducibility of intravoxel incoherent motion in body DWI technique for normal lumbar disc scanning

作者：王媛[1];周晟[2];王闻奇[2];陈晓飞[2];董馥闻[2];祁艳梅[1]

第一作者：王媛

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医院放射科,甘肃兰州730050

第一机构：甘肃中医药大学

年份：2019

卷号：35

期号：6

起止页码：970

中文期刊名：实用放射学杂志

外文期刊名：Journal of Practical Radiology

收录：CSTPCD;;北大核心:【北大核心2017】；

语种：中文

中文关键词：体素内不相干运动扩散加权成像;腰椎间盘退变;腰椎间盘;磁共振成像;Pfirrmann分级

外文关键词：intravoxel incoherent motion in body diffusionGweighted imaging;intervertebral disc degeneration;lumbar intervertebral disc;magnetic resonance imaging;Pfirrmann grading system

摘要：目的探讨体素内不相干运动扩散加权成像(IVIMGDWI)对正常腰椎间盘扫描的可重复性。方法经知情同意纳入50例健康志愿者,男30例,女20例,年龄21~30岁,平均(25.20±2.04)岁。利用3.0TMR,先行腰椎矢状位T1WI序列,矢状位、轴位T2WI序列和矢状位IVIMGDWI序列扫描1次,间隔4h再行第2次矢状位IVIMGDWI序列扫描。IVIMGDWI序列采用10个b值(0、10、20、40、60、80、100、200、400、600s/mm^2)。参照Pfirrmann分级标准对椎间盘进行分级。由2名医师在后处理工作站测得IVIMGDWI扫描每个椎间盘的快速ADC(ADCfast)、慢速ADC(ADCslow)、灌注分数(f)值。采用配对t检验分析2次扫描ADCfast、ADCslow、f值是否有差异,采用组内相关系数(ICC)分析2次采集的ADCfast、ADCslow、f值的一致性(P<0.05)和不同观察者对椎间盘ADCfast、ADCslow、f值测量的一致性(P<0.05),从而评价IVIMGDWI技术测量正常腰椎间盘的可重复性。结果50例健康志愿者的椎间盘中,符合标准(Pfirrmann分级为Ⅰ、Ⅱ级)的椎间盘共纳入230个。2次扫描的ADCslow值差异有统计学意义(t=2.460,P<0.05),ADCfast、f值差异无统计学意义(t=-0.418、1.273,P>0.05);2次扫描的ADCfast、ADCslow、f值的差异有统计学意义,一致性一般(ICC=0.478、0.306、0.316,P<0.05)。不同观察者对椎间盘ADCfast、ADCslow、f值的测量的一致性好(ICC=0.929、0.909、0.911,P<0.05)。结论IVIMGDWI技术对正常腰椎间盘扫描在不同观察者间测量一致性好。IVIMGDWI技术对正常腰椎间盘2次扫描一致性一般,由于ADCslow表现的是组织的水分子扩散情况,这可能是因为2次扫描时间有间隔,所以腰椎间盘内的微环境发生了变化,而导致ADCslow值的差异。关于扫描时间不同可能会导致IVIMGDWI数据的变化问题,笔者将会进一步研究。
Objective To investigate the reproducibility of magnetic resonance intravoxel incoherent motion in body diffusionG weighted imaging (IVIMGDWI)for normal lumbar disc scanning.Methods 50 healthy volunteers were enrolled with informed consent,30 males and 20 females,2 5.20±2.04 years old.Using 3.0T MR on the lumbar spine,the sagittal T1 WI,the sagittal,axial T2 WI and sagittal IVIMGDWI sequences were scanned once,then the second sagittal IVIMGDWI sequence was scanned after 4 hours.The IVIMGDWI sequence used 10 b values (0,10,20,40,60,80,100,200,400,600 s/mm^2 ).The discs were graded according to the Pfirrmann grading standard.The ADCfast ,ADCslow ,and f values of each intervertebral disc were measured by two doctors at the postGprocessing workstation.Paired tGtest was used to analyze whether there was a difference between the two scans.The intraGgroup correlation coefficient (ICC)was used to analyze the consistency of the ADCfast ,ADCslow ,and f values of the two acquisitions (P<0.05)and the consistency of the ADCfast ,ADCslow,and f values between the different doctors (P<0.05).The IVIMGDWI imaging was evaluated to measure the repeatability of normal lumbar discs. Results Of the 50 healthy volunteers,230 intervertebral discs matched the criteria(Pfirrmann gradeⅠandⅡ).The ADCslowvalue between the two scans was significantly different (t=2.460,P<0.05),and the differences in ADCfast and f values were not significant (t=-0.418,1.273,P>0.05). The consistency of ADCfast ,ADCslow ,and f values for the two scans were generally (ICC=0.478,0.306,0.316,P<0.05 ).Different observers had good consistency in the measurement of interverG tebral disc ADCfast ,ADCslow,and f values (ICC=0.929,0.909, 0.9 1 1 ,P<0.05).Conclusion The IVIMGDWI imaging has good consistency in the measurement of normal lumbar disc between different observers.The consistency of IVIMGDWI in two scans of normal lumbar intervertebral discs is general,which may be due to the time interval between the two scans.Because ADCslow represents the diffusion of water molecules in tissues,the microenvironment in the lumbar intervertebral disc has changed,resulting in the difference of ADCslow value.As for the problem that different scanning time may lead to the change of IVIMGDWI data,we will study it further.