文献类型：期刊文献

英文题名：Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography

作者：Chen, Xiaofen[1,2,3];Huang, Xinyi[1,2];Wang, Gaohong[1,2,3];Zhang, Jia[5];Di, Duolong[1,2,4]

第一作者：Chen, Xiaofen

通信作者：Di, DL[1]

机构：[1]Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[2]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China;[4]Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Resource Chem & New Mat, Qingdao 266100, Peoples R China;[5]Gansu Coll Tradit Chinese Med, Dept Pharm, Lanzhou 730000, Peoples R China

第一机构：Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.

年份：2014

卷号：26

期号：8

起止页码：2271

外文期刊名：ASIAN JOURNAL OF CHEMISTRY

收录：;Scopus(收录号：2-s2.0-84901044917);WOS:【SCI-EXPANDED(收录号:WOS:000335837800019)】；

基金：This research was supported by the Natural Sciences Foundation of China (NSFC No. 21175142), the "Hundred Talents Program" of the Chinese Academy of Sciences (CAS) and West Light Foundation of The Chinese Academy of Science and Open Fund of Key Laboratory of Chemistry of Northwestern Plant Resources of The Chinese Academy of Science (No. CNPR-2011kfkt-02).

语种：英文

外文关键词：Counter current chromatography; Ionic liquids; Tea polyphenols

摘要：In order to research the effect of ionic liquid as additives in two-phase solvent system on the behaviour of counter-current chromatography and develop more efficient methods of preparative separation and purification for natural products, a series of imidazolium-based ionic liquids with anion of [BF4]-(1-methyl-3-methylimidazolium tetrafluoroborate, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-propyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate) and four structurally similar tea polyphenols ((-)-epigallocatechin-3-gallate, (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-gallocatechin gallate) were, respectively chosen as additives and model molecules. The results showed that with the additive of 0.6 mol/L [MMIM][BF4] in ethyl acetate-water solvent system, the K values of (-)-epicatechin-3-gallate could drop from 30.46 to 3.47. The process of screening solvent systems based on ionic liquids was simpler and more efficiency than traditional ways. Subsequently, IR and NMR spectrum were performed to investigate the interactions between tea polyphenols and ionic liquids. It was considered that the major interaction between ionic liquid and target compounds was electrostatic attraction.