详细信息
MicroRNA调控成骨分化与骨质疏松症相关性研究进展 被引量:11
Research progress in micro RNA regulated osteogenic differentiation and osteoporosis
文献类型:期刊文献
中文题名:MicroRNA调控成骨分化与骨质疏松症相关性研究进展
英文题名:Research progress in micro RNA regulated osteogenic differentiation and osteoporosis
作者:姜徽[1];谢兴文[2];李宁[1]
第一作者:姜徽
机构:[1]甘肃中医学院,兰州730000;[2]甘肃省中医药研究院,兰州730050
第一机构:甘肃中医药大学
年份:2014
卷号:20
期号:3
起止页码:338
中文期刊名:中国骨质疏松杂志
外文期刊名:Chinese Journal of Osteoporosis
收录:CSTPCD;;北大核心:【北大核心2011】;CSCD:【CSCD_E2013_2014】;
语种:中文
中文关键词:MicroRNA;骨髓间充质干细胞;成骨分化;信号通路;骨质疏松症
外文关键词:miRNA;Bone marrow mesenchymal stem cells;Osteogenic differentiation;Signal pathway;Osteoporosis
摘要:成骨分化抑制或减弱是骨质疏松症发病的重要因素之一,通过对骨代谢相关微小RNA(MicroRNA,miRNA)的深入研究,发现其表达与成骨分化密切相关,本文通过对miRNA调控成骨分化的研究现状及其机制作详细阐述,旨在为骨质疏松症的发病与诊疗提供一定的理论依据。
The inhibition or weakening of osteogenic differentiation is one of the important factors of osteoporosis.The in-depth researches of bone metabolism-related microRNA ( miRNA ) reveal a close relationship between the expression of miRNA and osteogenic differentiation.This paper elaborates the research status of osteogenic differentiation regulated by miRNA and its mechanisms, aiming at providing a theoretical basis for the pathogenesis and treatment of osteoporosis.
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