文献类型：期刊文献

中文题名：伪基因在肝癌中的研究进展

英文题名：Research Progress of Pseudogenes in Hepatocellular Carcinoma

作者：李凯欣[1];陈彻[1];赵彦玉[1];郭文杰[1];刘芳[1]

第一作者：李凯欣

机构：[1]甘肃中医药大学研究生院公共卫生学院,兰州730000

第一机构：甘肃中医药大学党委研究生工作部、研究生院|甘肃中医药大学公共卫生学院

年份：2023

卷号：50

期号：8

起止页码：813

中文期刊名：肿瘤防治研究

外文期刊名：Cancer Research on Prevention and Treatment

收录：CSTPCD;;Scopus

基金：甘肃省自然科学基金项目(20JR10RA311)。

语种：中文

中文关键词：伪基因;肝癌;增殖;凋亡;侵袭转移;预后标志物;治疗靶点

外文关键词：Pseudogene;Liver cancer;Proliferate;Apoptosis;Invasion and metastasis;Prognostic marker;Therapeutic target

摘要：最初伪基因被认为没有任何功能,用“垃圾基因”等别名称呼。随着大规模基因组学项目和越来越多实验研究的出现,表明伪基因在实体瘤的发生发展中起重要作用,尤其在肝癌的发生发展过程中起重要调节作用,如参与调控肝癌细胞增殖、凋亡、侵袭转移、免疫等。近期研究表明,伪基因在肝癌中可以充当致癌基因和肿瘤抑制因子的调控因子,并可作为肝癌的预后标志物甚至治疗靶点。本文系统总结了目前不同伪基因在肝癌中的机制和功能,并对伪基因作为肝癌治疗靶点的未来作出展望。
Pseudogenes were initially thought to have no function and were called by aliases,such as“junk genes.”With the emergence of large-scale genomics projects and more and more experimental studies,pseudogenes have been shown to play an important role in the occurrence and development of solid tumors,especially playing an important regulatory role in the occurrence and develepment of liver cancer,such as regulating the proliferation,apoptosis,invasion,metastasis,and immunity of liver cancer cells.Recent studies showed that pseudogenes can act as regulators of oncogenes and tumor suppressors in hepatocellular carcinoma(HCC)and can thus serve as prognostic markers and even therapeutic targets for this cancer type.In this review,we systematically summarize the mechanisms and functions of different pseudogenes in HCC and present their future prospects as therapeutic targets.