文献类型：期刊文献

英文题名：PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib

作者：Zhu, P.[1];Cui, N.[2];Song, Z. -Y[3];Yong, W. -X[4];Luo, X. -X;Wang, G. -C[3];Wang, X.[3];Wu, Y. -N[1];Xu, Q.[1];Zhang, L. -M[1];Hao, G. -X.[1];Liu, Y.[1];Zhang, Z. -M[5,6]

第一作者：Zhu, P.

通信作者：Zhang, ZM[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Dept Gynecol, Beijing, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Dept Emergency, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Dept Ophthalmol, Lanzhou, Gansu, Peoples R China;[6]Gansu Prov Hosp Tradit Chinese Med, Famous Med Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Famous Med Ctr, Lanzhou, Gansu, Peoples R China.

年份：2022

卷号：26

期号：23

起止页码：8924

外文期刊名：EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

收录：;Scopus(收录号：2-s2.0-85144066756);WOS:【SCI-EXPANDED(收录号:WOS:000942569200007)】；

基金：This work was supported by the Science and Technology Planning Project of Gansu Province (18JR2FA001) , Youth Project of Gansu University of Chinese Medicine (ZQN2016- 16) , Open Project of Traditional Medicine Research Centre of Gansu Province (zyzy-2020-03) , Science and technolo- gy plan project for Gansu Province (GAN [2022] 1) and Talent project for Gansu province (2021 -RC -80) .

语种：英文

外文关键词：Lung adenocarcinoma; PRC1; Tumor-infiltrating im-mune cells; TCGA

摘要：OBJECTIVE: Lung adenocarci-noma (LUAD) is one of the most common can-cers in the world. Protein regulator of cytokine-sis 1 (PRC1) plays a role in the tumorigenesis and development of several cancers, including LUAD. The aim of the present study is to assess the characteristics of PRC1 in LUAD in order to find a potential drug that targets PRC1. MATERIALS AND METHODS: We investigat-ed the prognostic value of PRC1 in patients with LUAD using Cox analysis of the RNA sequenc-ing data from The Cancer Genome Atlas (TCGA) portal. A link between PRC1 and LUAD progres-sion, cigarette smoking mutation count, aneu-ploidy, and hypoxia scores was assessed. The relationship between PRC1 and tumor -infiltrat-ing immune cells in LUAD was analyzed and Gene Set Enrichment Analysis (GSEA) was used to study the PRC1-related biological process and signal pathways. Potential drugs targeting PRC1 were identified using DrugBank database and molecular docking. RESULTS: PRC1 expression was significantly increased in LUAD. PRC1 could be, therefore, a prognostic biomarker for predicting overall sur-vival in LUAD. PRC1 expression was also related to cancer stage and patient's smoking history. PRC1 positively correlated with mutation count, aneuploidy and hypoxia scores. It was also sig-nificantly related to tumor-infiltrating immune cells, especially the activated mast cells. GSEA revealed that PRC1 might be correlated with cell cycle, cytokinesis and p53 signaling pathway. Additionally, fostamatinib was found to be a po-tential drug targeting PRC1. CONCLUSIONS: PRC1 may have a prognos-tic value for patients with LUAD, and be correlat- ed with the mutation count, aneuploidy, hypox-ia and tumor-infiltrating immune cells. Fostama-tinib was found to be a potential drug targeting PRC1 in LUAD.