文献类型：期刊文献

英文题名：Astragalus polysaccharide restores activation of NK cells in radiation therapy of tumors

作者：Mu, Ji-Ying[1];Li, Ying-Dong[1,2];Zhao, Xin-Ke[3];Li, Juan[1];Yang, Ai-Jun[1]

第一作者：Mu, Ji-Ying

通信作者：Li, YD[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Inst Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：12

期号：7

起止页码：8609

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000477991300074)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities lzujbky-2016-68 and by the Open Fund for Key Laboratory of Chinese Medicine Prevention and Control of Chronic Diseases in Gansu Province GSMBKY2015-05.

语种：英文

外文关键词：Astragalus polysaccharide; NK cells; radiotherapy

摘要：Astragalus polysaccharide (APS) has been used as an adjuvant in the treatment of malignant tumors, however, most APS trials have been performed with chemotherapy of malignant tumors, the effect and mechanism of APS is unclear in radiotherapy for tumors. In the present study, the hepatocellular carcinoma H22 tumor-bearing mouse model was established. The H22 tumor-bearing mice received radiotherapy combined with APS treatment. Results showed APS could obviously up-regulate the expression of MHC class I chain-related molecule A (MICA) and B (MICB) on tumor cell surface, which is one of the major ligands of activating receptor NKG2D on natural killer cells (NK cells). The binding of MICA/B and NKG2D led to NK cell activation by improving the level of phosphorylated extracellular signal regulated kinase on NK cells. Activated NK cells released more IFN-gamma, Granzyme B and Perforin, promoting the clearance of tumor cells. These results suggested that APS increased the sensitivity of tumors to radiotherapy by activating the extracellular signal regulated kinase pathway of NK cells. APS may be as an efficient adjuvant in radiotherapy of malignant tumors.