文献类型：期刊文献

英文题名：Advances in cellular and molecular pathways of salivary gland damage in Sj?gren's syndrome

作者：Qi, Wenxia[1];Tian, Jiexiang[2];Wang, Gang[2];Yan, Yanfeng[3];Wang, Tao[2];Wei, Yong[1,2];Wang, Zhandong[1];Zhang, Guohua[1];Zhang, Yuanyuan[1,2];Wang, Jia[1]

第一作者：齐文萱;齐文宣

通信作者：Wang, G[1]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Integrat Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Rheumatol & Orthoped, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Resp & Crit Care Med, Affiliated Hosp 4, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Rheumatol & Orthoped, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85199345015);WOS:【SCI-EXPANDED(收录号:WOS:001274576100001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The research was supported by two National Natural Science Foundation of China (81960832, 81860858) and the Natural Science Foundation of Gansu Province for 2 projects (21JRI1RA158, 22JR11RA131).

语种：英文

外文关键词：Sj & ouml;gren's syndrome; salivary gland damage; pathomechanisms; cellular; molecular biology

摘要：Sj & ouml;gren's Syndrome (SS) is an autoimmune disorder characterized by dysfunction of exocrine glands. Primarily affected are the salivary glands, which exhibit the most frequent pathological changes. The pathogenesis involves susceptibility genes, non-genetic factors such as infections, immune cells-including T and B cells, macrophage, dendritic cells, and salivary gland epithelial cells. Inflammatory mediators such as autoantibodies, cytokines, and chemokines also play a critical role. Key signaling pathways activated include IFN, TLR, BAFF/BAFF-R, PI3K/Akt/mTOR, among others. Comprehensive understanding of these mechanisms is crucial for developing targeted therapeutic interventions. Thus, this study explores the cellular and molecular mechanisms underlying SS-related salivary gland damage, aiming to propose novel targeted therapeutic approaches.