文献类型：期刊文献

英文题名：Opportunities and challenges of targeting c-Met in the treatment of digestive tumors

作者：Zhang, Zhengchao[1,2];Li, Dong[1];Yun, Heng[1];Tong, Jie[1];Liu, Wei[1];Chai, Keqiang[1];Zeng, Tongwei[1];Gao, Zhenghua[1];Xie, Yongqiang[1]

第一作者：Zhang, Zhengchao

通信作者：Gao, ZH[1];Xie, YQ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Dept Gen Surg, Affiliated Hosp 3, Baiyin, Peoples R China;[2]Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Gen Surg, Affiliated Hosp 3, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：12

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85136224767);WOS:【SCI-EXPANDED(收录号:WOS:000841639900001)】；

基金：This study was funded by the Third Affiliated Hospital of Gansu University of Chinese Medicine (Project Approval Number: 2016YG-06) and Baiyin City 2019 Science and technology plan project (Project Approval Number: 20191-22Y).

语种：英文

外文关键词：c-Met; digestive system tumors; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; targeted therapy; adoptive immunotherapy

摘要：At present, a large number of studies have demonstrated that c-Met generally exerts a crucial function of promoting tumor cells proliferation and differentiation in digestive system tumors. c-Met also mediates tumor progression and drug resistance by signaling interactions with other oncogenic molecules and then activating downstream pathways. Therefore, c-Met is a promising target for the treatment of digestive system tumors. Many anti-tumor therapies targeting c-Met (tyrosine kinase inhibitors, monoclonal antibodies, and adoptive immunotherapy) have been developed in treating digestive system tumors. Some drugs have been successfully applied to clinic, but most of them are defective due to their efficacy and complications. In order to promote the clinical application of targeting c-Met drugs in digestive system tumors, it is necessary to further explore the mechanism of c-Met action in digestive system tumors and optimize the anti-tumor treatment of targeting c-Met drugs. Through reading a large number of literatures, the author systematically reviewed the biological functions and molecular mechanisms of c-Met associated with tumor and summarized the current status of targeting c-Met in the treatment of digestive system tumors so as to provide new ideas for the treatment of digestive system tumors.