文献类型：期刊文献

中文题名：miRNA调控H型血管在骨代谢疾病中的作用机制及中药活性成分干预作用研究进展

英文题名：Research progress on mechanism of miRNA regulating H-type blood vessels in bone metabolic diseases and intervention effect of active ingredients of traditional Chinese medicines

作者：樊佳煊[1];张维[1];崔瑞[1];曹林忠[1,2]

第一作者：樊佳煊

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730030

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：41

期号：4

起止页码：606

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(No.82160915);兰州市科技局项目(No.2022-3-23)。

语种：中文

中文关键词：microRNA;H型血管;成血管-成骨耦联;骨稳态;骨代谢;中药活性成分

外文关键词：microRNA;H-type vessel;angiogenesis-osteogenesis coupling;bone homeostasis;bone metabolism;active ingredients of traditional Chinese medicine

摘要：微小RNA(microRNA,miRNA)作为短链非编码RNA分子,通过转录翻译、剪切结合等过程,调节骨免疫信号、应激反应,发挥促血管生成、损伤骨修复等功能;H型血管在新骨形成中发挥成血管-成骨耦联作用,促进缺损部位骨再生。近年miRNA调控缺氧诱导因子-1α(hypoxia inducible factor 1α,HIF-1α)/血管内皮生长因子(vascular endothelial growth factor,VEGF)、Notch、血小板衍生生长因子-BB(platelet-derived growth factor-BB,PDGF-BB)、Wnt/糖原合成激酶3β(glycogen synthase kinase-3β,GSK3β)等影响内皮细胞(endothelial cells,ECs)、成骨细胞(osteoblast,OB)迁移募集、增殖分化,促进H型血管-成骨耦联以改善骨稳态,进而防治骨代谢疾病。该文阐释miRNA调控H型血管-成骨耦联中的作用,以期为改善骨稳态提供靶点与通路;此外,中药活性成分影响miRNA差异性表达来促进H型血管新生,为临床防治骨代谢疾病提供策略。
microRNA(miRNA),as a short non-coding RNA molecule,regulates bone-immune signal and stress response through transcription,translation as well as the combination of shear process,exerting the effect of promoting angiogenesis and repairing damage bone;type H vessels play a role in the coupling of angiogenesis and osteogenesis in the formation of new bone and promoting bone regeneration at the defect site.In recent years,miRNA regulates hypoxia inducible factor 1α(HIF-1α)/vascular endothelial growth factor(VEGF),Notch,platelet-derived growth factor-BB(PDGF-BB),Wnt/glycogen synthase kinase-3β(GSK3β)to affect the migration,recruitment,proliferation and differentiation of endothelial cells(ECs)and osteoblast(OB),promote the coupling of H-type vessels and osteoblasts to improve bone homeostasis,and then prevent and treat bone metabolic diseases.This article explains the role of miRNA in regulating H-type vascular osteogenic coupling to provide targets and pathways for improving bone homeostasis.In addition,the active ingredients of traditional Chinese medicine affect the differential expression of miRNA to promote H-type angiogenesis and provide strategies for clinical prevention and treatment of bone metabolic diseases.