文献类型：期刊文献

英文题名：Lactiplantibacillus plantarum LZU-J-Q21 enhanced the functional metabolic profile and bioactivity of Cistanche deserticola

作者：Liu, Kangkang[1];Li, Junxiang[2,3];Hao, Wenting[4];Li, Jingjing[1];Khan, Israr[2,3];Liang, Yibo[5];Wang, Haijuan[1];Li, Xiaofeng[2];Zhang, Chunjiang[2,3]

第一作者：Liu, Kangkang

通信作者：Li, XF[1];Zhang, CJ[1]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730101, Peoples R China;[2]Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China;[3]Lanzhou Univ, Key Lab Cell Act & Stress Adaptat, Minist Educ, Lanzhou 730000, Peoples R China;[4]Ctr Pharmacovigilance Gansu Prov, Lanzhou 730070, Peoples R China;[5]Gansu Inst Drug Control, Lanzhou 730030, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.

年份：2024

卷号：24

外文期刊名：FOOD CHEMISTRY-X

收录：;EI(收录号：20244517324128);Scopus(收录号：2-s2.0-85208105619);WOS:【SCI-EXPANDED(收录号:WOS:001352854300001)】；

基金：This work was supported by the Science and Technology Major Project of Gansu Province (Grant no. 22ZD1FA001, 24ZDNA003), the Science and Technology Major Project of Gansu Province-Enterprise Innovation Consortium Project (Grant no. 23ZDFA013-3), the Guangz-hou Science and Technology Planning Project (Grant no. 202206010165), and the Key Talent Project of Gansu Province (Grant no. 2022RCXM027). We would like to express our gratitude to the Core Facility of the School of Life Sciences, Lanzhou University for their support. Additionally, we acknowledge the assistance provided by Suzhou Panomix (https:// www.panomix.com /), and LetPub ( www.letpub.com ) for linguistic assistance and pre-submission expert review.

语种：英文

外文关键词：Cistanche deserticola; Submerged fermentation; Anti-fatigue; Metabolic profile

摘要：Microbial fermentation is an effective method to enhance the bioavailability of herbs. This study utilized Lactiplantibacillus plantarum LZU-J-Q21 to ferment Cistanche deserticola and evaluated its metabolic properties and biological activity. Results showed that the contents of total acid and flavone, and the clearance rates of DPPH, ABTS and OH- in fermented Cistanche deserticola (FCD) were increased by 142.74 %, 56.45 %, 58.1 %, 62.3 %, 51.2 %, compared with non-fermented Cistanche deserticola (NFCD). The metabolic profile of FCD had remarkable changes, especially elevated glucose and adenosine (97.31 % and 59.18 %). Further, FCD increased the weight-bearing swimming time of mice by 88.57 %, reduced fatigue markers BUN, BLA, and MDA (18.47 %, 12.92 %, and 15.16 %), and enhanced liver/muscle glycogen and SOD (28.99 %, 28.57 %, and 14.47 %). The investigation into its anti-fatigue mechanism suggested that FCD enhanced GS protein expression by activating PI3K/AKT/GSK3 beta signaling. These findings suggest that FCD enhances anti-fatigue effects by modifying its metabolic properties and biological activity.