文献类型：期刊文献

中文题名：产前超声诊断孕期胆囊未显示胎儿临床预后分析

英文题名：Clinical outcomes after sonographic diagnosis of non-visualization of fetal gallbladder

作者：郭文静[1];王萍[2];铁红霞[3];李天刚[3]

第一作者：郭文静

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]临夏州妇幼保健院超声科,甘肃临夏731100;[3]甘肃省妇幼保健院超声科,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：14

期号：5

起止页码：78

中文期刊名：中国计划生育和妇产科

外文期刊名：Chinese Journal of Family Planning & Gynecotokology

收录：CSTPCD

语种：中文

中文关键词：产前超声;胎儿;胆囊

外文关键词：prenatal ultrasound;fetus;gallbladder

摘要：目的探讨产前超声诊断孕期胆囊未显示胎儿的临床预后。方法回顾性分析甘肃省妇幼保健院2015年2月至2019年11月产前超声诊断中孕期及孕晚期胎儿胆囊均未显示的44例临床资料与超声图像,依据超声提示分为非孤立性胆囊未显示组和孤立性胆囊未显示组,对每组新生儿追踪随访至6月以上并判断其预后。结果孤立性胆囊未显示组共34例,其中出生后胆囊正常显示26例,胎死宫内1例,出生后不明原因死亡1例(未做尸检),出生后患有胆道系统疾病6例(胆道闭锁2例,胆囊缺如2例,胆道闭锁合并胆囊缺如1例,胆管堵塞1例);非孤立性胆囊未显示组共10例,5例合并多系统畸形或重大畸形孕期引产,2例十二指肠闭锁,2例永久性右脐静脉,1例生殖系统囊肿。两组胆道闭锁率比较,差异无统计学意义(P>0.05),随访半年非孤立性胆囊未显示组不良结局高于孤立性胆囊未显示组,差异有统计学意义(P<0.05)。结论孕期孤立性胆囊未显示胎儿大部分预后较好,部分出生后发生胆道系统疾病概率增加,以胆道闭锁和胆囊缺如发生率最高;影响非孤立性胆囊未显示胎儿预后的主要是合并畸形,其中以消化系统畸形最高,尤其应当警惕十二指肠闭锁的发生。
Objective To explore the clinical prognosis of the fetus whose gallbladder does not show during pregnancy in prenatal ultrasound diagnosis.Methods A retrospective analysis of the clinical data and ultrasound images of 44 cases of the fetal with non-visualization of gallbladder in the middle and third trimesters during the prenatal ultrasound diagnosis from February 2015 to November 2019 in Gansu Province Maternal and Child Health Hospital was analyzed.According to the results of prenatal ultrasound diagnosis, they were divided into isolated non-visualization of the fetal gallbladder(NVFGB) group and non isolated NVFGB group.The newborns in each group were followed up for more than 6 months and their prognosis was evaluated.Results There were 34 cases in the isolated NVFGB group, among them, 26 cases showed normal gallbladder after birth, 1 case of fetal death in utero, 1 case died of unknown cause after birth(no autopsy),6 cases of biliary system disease after birth(2 cases of biliary atresia, 2 cases of absence of gallbladder, 1 case of biliary atresia combined with absence of gallbladder, 1 case of bile duct blockage).There were 10 cases in non isolated NVFGB group, 5 cases had multiple system malformations or major malformations then selected induction, 2 had duodenal atresia, 2 had permanent right umbilical vein, and 1 had reproductive system cyst.There was no significant difference in the rate of biliary atresia between the two groups(P>0.05),and the adverse outcome of the non-isolated NVFGB group was higher than that of the isolated NVFGB group after six months of follow-up(P<0.05).Conclusion Most of the fetuses with isolated NVFGB have a good prognosis, and the incidence of biliary tract diseases is increased in some cases, especially biliary atresia and gallbladder absence.The main influencing factor of the prognosis of the non isolated NVFGB is the combined malformation, among which the digestive system malformation is the highest, particular attention should be paid to the occurrence of duodenal atresia.