文献类型：期刊文献

中文题名：针刺调节前扣带皮层功能改善痛情绪的研究进展

英文题名：Research progress of acupuncture in improving pain emotion by regulating functions of anterior cingulate cortex

作者：李丽[1];马翠[1];魏玉婷[1];严兴科[1]

第一作者：李丽

机构：[1]甘肃中医药大学针灸推拿学院,兰州730000

第一机构：甘肃中医药大学针灸推拿学院

年份：2024

卷号：49

期号：10

起止页码：1092

中文期刊名：针刺研究

外文期刊名：Acupuncture Research

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；PubMed;

基金：2023年甘肃省省级重点人才项目(No.甘组通字[2023]20号);甘肃省自然科学基金B类项目(No.21JR1RA266);国家自然科学基金项目(No.81460744)。

语种：中文

中文关键词：前扣带皮层;针刺;痛情绪;研究进展

外文关键词：Anterior cingulate cortex;Acupuncture;Pain emotion;Research progress

摘要：痛情绪是因疼痛引发的负性情绪,严重影响患者的身心健康。大脑前扣带皮层(ACC)是疼痛及痛情绪发生与调控的关键脑区,ACC内相关神经递质及受体、信号通路和神经环路均参与痛情绪的调控。针刺能有效改善痛厌恶情绪,减轻疼痛相关的焦虑、恐惧等负性情绪,其机制与针刺调节ACC功能密切相关,通过下调ACC内N-甲基-D-天冬氨酸受体(NMDAR)和γ-氨基丁酸受体(GABAR),上调相关阿片受体和神经肽S/神经肽S受体的表达,激活ACC中小白蛋白(PV)中间神经元等发挥作用。此外,针刺还可抑制ACC脑区蛋白激酶Cζ-谷氨酸受体1和环磷酸腺苷/蛋白激酶A-细胞外调节蛋白激酶-cAMP反元件结合蛋白信号通路发挥调节和改善痛情绪的作用。针刺抑制rACC^(Glu)-丘脑环路仅缓解痛情绪而不镇痛,抑制rACC^(Glu)-腹外侧中脑导水管周围灰质环路仅镇痛而不缓解痛情绪。
Pain emotion is a negative emotion caused by pain,which seriously affects the patients’physical and psychological health.The anterior cingulate cortex(ACC)is a key brain region in the occurrence and regulation of pain and painful emotion.In this paper,we summed up the relevant progress of researches on acupuncture improvement of pain emotion from neurotransmitters and receptors,cellular signaling pathways and neural circuits of ACC,in order to provide a basis for further research.1)Acupuncture can regulate the long-term potentiation of ACC synaptic transmission by down-regulating the expression of N-methyl-D-aspartic acid receptor(NMDAR);and upregulating the expression ofμ-,delta-andκ-opioid receptors,neuropeptide S(NPS)/NPS receptor,and the number of parvalbumin-expressing interneurons to reduce neuronal excitability,relieving pain emotion;2)Acupuncture can regulate synaptic transmission of ACC neurons by inhibiting protein kinase Mζ(PKMζ)-GluR1 and cAMP/PKA-ERKCREB signaling pathways,and modulate synaptic plasticity to ameliorate pain emotion;3)Acupuncture intervention induced inhibition of rostral ACC^(Glu)-thalamic circuit may result in relief of pain emotion but not pain sensation,whereas inhibition of the rostral ACC^(Glu)-ventrolateral periaqueductal gray matter(vlPAG)circuit may relieve pain sensation but not pain emotion.In addition,our team found that in the treatment of painful diseases by acupuncture,the addition of“spiritregulating”acupoints can not only improve patients’negative emotion,but also significantly relive patients’pain sensation.