文献类型：期刊文献

英文题名：Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines

作者：Liang, Lijuan[1,2];Mi, Youjun[3];Zhou, Shihan[1];Yang, Aojian[1];Wei, Chaoyu[1];Dai, Enlai[1]

第一作者：梁丽娟;Liang, Lijuan

通信作者：Dai, EL[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Minist Educ, Key Lab Dunhuang Med & Translat, Lanzhou, Peoples R China;[3]Lanzhou Univ, Inst Pathophysiol, Sch Basic Med Sci, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85212181755);WOS:【SCI-EXPANDED(收录号:WOS:001377704600001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Science Foundation of China (No.82160852), Technology Innovation Project of Gansu Provincial Department of Education (No.2022B-118), Laboratory of Dunhuang Medical and Translational Education Ministry Project (No. DHXY20-08). State Administration of Traditional Chinese Medicine Inheritance and Innovation Program of Traditional Chinese Medicine Batch 7 Teacher Training Funding Project (No. 20461903). Key R&D Projects of Gansu Academy of Sciences (No.2024ZDYF-05).

语种：英文

外文关键词：renal fibrosis; chronic kidney disease; pathogenesis; signaling pathways; traditional Chinese medicine; treatment

摘要：Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, leading to the activation of molecular signaling pathways involved in fibrosis. This article discusses the key cells, molecules, and signaling pathways implicated in the pathogenesis of RF, with a particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition (EMT), and transforming growth factor-beta(TGF-beta)/Smad signaling. These factors drive the core and regulatory pathways that significantly influence RF. A comprehensive understanding of their roles is essential. Through a literature review, we explore recent advancements in traditional Chinese medicine (TCM) aimed at reducing RF and inhibiting chronic kidney disease (CKD). We summarize, analyze, and elaborate on the important role of Chinese herbs in RF, aiming to provide new directions for their application in prevention and treatment, as well as scientific guidance for clinical practices.