文献类型：期刊文献

英文题名：Amlodipine/atorvastatin has an effect on vascular function and normal lipid levels

作者：Zhao Xin-ke[1];Feng Ming-xia[2];Qiao Ai-ling[3];Liu Kai[1];Zhang Xu[4];Li Ying-dong[1,2,5]

第一作者：Zhao Xin-ke

通信作者：Li, YD[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]MJR PharmJet GmbH, Uberherrn, Germany;[4]Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China;[5]Key Lab Prevent & Treatment Chron Dis Tradit Chin, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China.

年份：2017

卷号：28

期号：9

起止页码：3821

外文期刊名：BIOMEDICAL RESEARCH-INDIA

收录：;Scopus(收录号：2-s2.0-85019765313);WOS:【SCI-EXPANDED(收录号:WOS:000403460100006)】；

语种：英文

外文关键词：Vascular endothelial function; Pulse wave velocity; Amlodipine/atorvastatin

摘要：Objective: To investigate whether the use of amlodipine/atorvastatin can affect vascular endothelial function as well as blood vessel elasticity and lipid level compared with hypotensor alone. Method: There were 162 participants selected into domestic compound hypotensive tablets (Group 1), amlodipine tablets (Group 2) and amlodipine/atorvastatin group (Group 3) randomly. After 3 months, 144 participants remained. Each participant's medical history was collected, and each participant underwent a blood biochemical examination including high-sensitivity C-Reactive Protein (hs-CRP), Flow-Mediated-Dilation (FMD) and Endothelium-Independent Dilatation (EID), and carotid-Femoral Pulse Wave Velocity (c-f PWV) before and after the 3-month follow-up period. Results: Compared with baseline, the FMD values of all groups improved significantly. Group 3 showed the greatest difference, followed by Groups 2 and 1. In contrast, no difference in EID was noted (P>0.05 in three groups). After treatment, the c-f PWV of Groups 2 and 3 turned to be significantly better (P<0.05), while that of Group 1 did not change. There was no statistical significant difference among three groups. The lipid levels of the participants in Group 3 decreased, while those in Groups 1 and 2 did not change. The hs-CRP levels of Groups 2 and 3 decreased significantly, whereas that of Group 1 did not change. Conclusions: In conclusion, we found that Amlodipine/atorvastatin combination pills can improve vascular endothelial function as well as vascular elasticity, and down-regulate the level of hs-CRP.