文献类型：期刊文献

英文题名：How do we evaluate the remodeling and regeneration of absorbable meshes? Multi-dimensional evaluation parameters from multi-species

作者：Ding, Fengxing[1];Luo, Yating[1];Liu, Dengrui[2];Niu, Muting[3];Liu, Yanli[1];Yi, Shaowei[1];Du, Wanxian[1];Zhao, Yue[3];Wang, Zhe[1];Wang, Zihan[4];Wang, Yajuan[4];Liu, Wenbo[4];Ma, Bin[1,5,6]

第一作者：Ding, Fengxing

通信作者：Ma, B[1];Liu, WB[2];Ma, B[3];Ma, B[4]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Pediat Surg, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[4]Natl Med Prod Adm, Ctr Med Device Evaluat, Beijing, Peoples R China;[5]Lanzhou Univ, Med Device Regulatory Sci Res Ctr, Lanzhou, Peoples R China;[6]Gansu Prov Ctr Evidence Based Res & Evaluat Med De, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[2]corresponding author), Natl Med Prod Adm, Ctr Med Device Evaluat, Beijing, Peoples R China;[3]corresponding author), Lanzhou Univ, Med Device Regulatory Sci Res Ctr, Lanzhou, Peoples R China;[4]corresponding author), Gansu Prov Ctr Evidence Based Res & Evaluat Med De, Lanzhou, Peoples R China.

年份：2026

卷号：30

期号：1

外文期刊名：HERNIA

收录：;Scopus(收录号：2-s2.0-105031563813);WOS:【SCI-EXPANDED(收录号:WOS:001703152500002)】；

基金：This study was supported by the National Key Research & Development Program of China [2022YFC2409800] and [2022YFC2409801]. We would like to express our sincere gratitude to the funding agencies for their invaluable support. Additionally, the graphical abstract of this study was created on https://www.figdraw.com/static/index.html#/and we sincerely thank the staff of the website for their assistance.

语种：英文

外文关键词：Abdominal wall hernia; Absorbable mesh; Remodeling; Regeneration; Scoping review

摘要：Purpose This review aimed to systematically synthesize and standardize evaluation parameters for preclinical studies of absorbable meshes in abdominal wall hernia repair models. Methods A comprehensive database search was conducted to identify comparative studies on the remodeling and regenerative properties of absorbable meshes in animal models of abdominal wall hernia. Stratified analysis of dimensional indicators was performed across species, and study characteristics, epidemiological data, and key model attributes were visually summarized and analyzed. Results Remodeling and regenerative properties were assessed across seven major dimensions: inflammatory response, scaffold degradation, tissue integration, neovascularization, extracellular matrix (ECM) deposition, cellular infiltration, and fibrotic encapsulation. Evaluation methods encompassed histological analysis, molecular assays, general observation, and biomechanical testing, with outcomes reported in qualitative, quantitative, or combined formats. Inflammatory response, scaffold degradation, tissue integration, and neovascularization emerged as the most frequently assessed metrics. Histological assessment was the predominant evaluation method, and qualitative data presentation was most common. Species-stratified analysis revealed that rats and rabbits were the most frequently used models. Rat studies primarily focused on ECM deposition, inflammation, and tissue integration, whereas rabbit studies emphasized ECM deposition and inflammatory response. Conclusion Inflammatory response, scaffold degradation, tissue integration, neovascularization and ECM deposition constitute core dimensions for evaluating tissue remodeling and regeneration. However, current studies show substantial inconsistency in endpoint selection and dimensional emphasis, with limited diversity in measurement techniques and a lack of consensus across species-specific models. Future research should establish species-specific core outcome sets and adopt multidimensional strategies to enable comprehensive evaluation of absorbable mesh performance. [GRAPHICS]