文献类型：期刊文献

中文题名：改良中医情绪疗法联合帕罗西汀在抑郁症患者中的疗效观察及对外周血T淋巴细胞亚群的影响研究

英文题名：Efficacy observation of modified traditional Chinese medicine emotional therapy combined with paroxetine in patients with depression and influence of T lymphocyte subsets in peripheral blood

作者：赵剑华[1];张静霞[1];彭晓明[1];王晋阳[1];黄生辉[1];张洁[1]

第一作者：赵剑华

机构：[1]甘肃中医药大学附属医院

第一机构：甘肃中医药大学第二附属医院

年份：2019

卷号：35

期号：11

起止页码：1314

中文期刊名：中国免疫学杂志

外文期刊名：Chinese Journal of Immunology

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：甘肃省中医药管理局(GZK-2018-19);甘肃中医药大学附属医院院内课题(gzfy-2017-03)资助

语种：中文

中文关键词：改良中医情绪疗法;帕罗西汀;抑郁症;抑郁症状;炎症因子;T淋巴细胞水平

外文关键词：Improved TCM emotional therapy;Paroxetine;Depression;Depressive symptoms;Inflammatory factors;T lymphocyte levels

摘要：目的:探讨改良中医情绪疗法联合帕罗西汀在抑郁症患者中的疗效观察及对外周血T淋巴细胞亚群的影响。方法:选择2014年5月~2017年4月以抑郁症收治的90例患者作为对象,按照随机数字表法分为对照组( n =45)和观察组( n =45)。对照组采用帕罗西汀治疗,观察组在对照组基础上联合改良中医情绪疗法治疗,两组均进行1个月治疗,治疗完毕后对患者效果进行评估。采用汉密尔顿抑郁量表(HAMD)对两组患者治疗前、治疗后1个月从认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪进行评估;采用酶联免疫吸附实验测定两组患者治疗前、治疗后1个月白细胞介素-2(IL-2)和肿瘤坏死因子-α(TNF-α)水平;采用流式细胞仪测定两组患者治疗前、治疗后1个月CD3 ^+、CD4 ^+、CD8 ^+及CD4 +/CD8 ^+T细胞水平;记录并统计两组治疗后恶心、口干、便秘及头晕发生率,比较两组临床疗效及目标治疗对外周血T淋巴细胞水平的影响。结果:观察组治疗后1个月认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪评分均低于对照组( P <0.05);IL-2及TNF-α水平均低于对照组( P <0.05);CD3 ^+、CD4 ^+、CD4 ^+/CD8 ^+T细胞水平均高于对照组( P <0.05);CD8 ^+T细胞水平低于对照组( P <0.05)。观察组与对照组治疗后比较,恶心、口干、便秘及头晕发生率差异无统计学意义( P >0.05)。结论:将改良中医情绪疗法联合帕罗西汀用于抑郁症患者中有助于改善患者抑郁症状,降低炎症因子水平,能提高T淋巴细胞水平,值得推广。
Objective: To investigate the effect of improved traditional Chinese medicine(TCM) emotional therapy combined with paroxetine on patients with depression and T lymphocyte subsets in peripheral blood. Methods: Ninety patients admitted to depression from May 2014 to April 2017 were selected and divided into control group( n =45)and observation group( n =45)according to Random number table method.The control group was treated with paroxetine.The observation group was treated with modified TCM emotional therapy on the basis of the control group.Both groups were treated for 1 month.After the treatment,the patient′s effect was evaluated.The Hamilton depression scale(HAMD)was used to evaluate cognitive impairment,sleep disturbance,somatic anxiety,mental anxiety and mood before treatment and 1 month later.The two groups were treated by enzyme-linked immunosorbent assay to measure the levels of interleukin-2(IL-2)and tumor necrosis factor-α(TNF-α) before treatment and 1 month later;CD3 ^+,CD4 ^+,CD8^+ and CD4 +/CD8 ^+T cells were measured by flow cytometry before treatment and 1 month later.The incidence of nausea,dry mouth,constipation and dizziness after treatment were recorded and counted,and the clinical effects and T lymphocyte levels in peripheral blood were compared between the two groups. Results: The cognitive impairment,sleep disturbance,somatic anxiety,mental anxiety and emotional scores in the observation group were lower than those in the control group after treatment 1 month( P <0.05).The levels of IL-2 and TNF-α in the observation group were lower than those in the control group after treatment 1 month( P <0.05).The levels of CD3^+,CD4 ^+ and CD4 ^+/CD8 ^+T cells in the observation group were higher than those in the control group after treatment 1 month( P <0.05).The level of CD8 ^+T cells in the observation group was lower than that in the control group( P <0.05).There was no significant difference in the incidence of nausea,dry mouth,constipation and dizziness between the observation group and the control group( P >0.05). Conclusion: The improved TCM emotional therapy combined with paroxetine in patients with depression can improve the patient′s depressive symptoms,reduce the level of inflammatory factors,and increase the level of T lymphocytes,which is worthy of popularization and application.