文献类型：期刊文献

英文题名：Immunomics in one health: understanding the human, animal, and environmental aspects of COVID-19

作者：Gao, Jing[1,2,3,4,5];Zhang, Chutian[6];Wheelock, Asa M.[2,7];Xin, Siming[8];Cai, Hui[9];Xu, Lei[5,10];Wang, Xiao-jun[1,8]

第一作者：Gao, Jing

通信作者：Gao, J[1];Wang, XJ[1];Gao, J[2];Gao, J[3];Gao, J[4];Gao, J[5];Xu, L[5];Wang, XJ[6];Cai, H[7];Xu, L[8]

机构：[1]Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China;[2]Karolinska Inst, Ctr Mol Med, Dept Med Solna, Resp Med Unit, Stockholm, Sweden;[3]Univ Helsinki, Dept Pulm Dis, Helsinki, Finland;[4]Helsinki Univ Hosp, Helsinki, Finland;[5]Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China;[6]Northwest Agr & Forestry Univ, Coll Nat Resources & Environm, Yangling, Peoples R China;[7]Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden;[8]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[9]Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China;[10]Tsinghua Univ, Inst Hlth China, Beijing, Peoples R China

第一机构：Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China;[2]corresponding author), Karolinska Inst, Ctr Mol Med, Dept Med Solna, Resp Med Unit, Stockholm, Sweden;[3]corresponding author), Univ Helsinki, Dept Pulm Dis, Helsinki, Finland;[4]corresponding author), Helsinki Univ Hosp, Helsinki, Finland;[5]corresponding author), Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China;[6]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[7]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China;[8]corresponding author), Tsinghua Univ, Inst Hlth China, Beijing, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85204418350);WOS:【SCI-EXPANDED(收录号:WOS:001314622900001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. JG was supported by Karolinska Institutet Research Foundation Grants (2022-02329, Sweden), the Vaino and Laina Kivi Foundation (JG-2023, Finland), The Research Foundation of the Pulmonary Diseases (JG-2024, Finland), and Gansu Provincial People's Hospital Research Funding (JG-2024, China). HC was supported by the Gansu Joint Scientific Research Fund Major Project of China (Grant No.23JRRA1537). XJW was supported by the Science- Technology Foundation for Scientist of the Gansu Province of China (Grant no.21JR7RA595), the Science-Technology Foundation for Scientist of the Lanzhou City of China (Grant no.2023-2-54), and the Scientists Fund of the Gansu Provincial Hospital of China (Grant no.23JRRA1758).

语种：英文

外文关键词：immunomics; one health; SARS-CoV2; COVID-19; immunology

摘要：The coronavirus disease 2019 (COVID-19) pandemic underscores the critical need to integrate immunomics within the One Health framework to effectively address zoonotic diseases across humans, animals, and environments. Employing advanced high-throughput technologies, this interdisciplinary approach reveals the complex immunological interactions among these systems, enhancing our understanding of immune responses and yielding vital insights into the mechanisms that influence viral spread and host susceptibility. Significant advancements in immunomics have accelerated vaccine development, improved viral mutation tracking, and broadened our comprehension of immune pathways in zoonotic transmissions. This review highlights the role of animals, not merely as carriers or reservoirs, but as essential elements of ecological networks that profoundly influence viral epidemiology. Furthermore, we explore how environmental factors shape immune response patterns across species, influencing viral persistence and spillover risks. Moreover, case studies demonstrating the integration of immunogenomic data within the One Health framework for COVID-19 are discussed, outlining its implications for future research. However, linking humans, animals, and the environment through immunogenomics remains challenging, including the complex management of vast amounts of data and issues of scalability. Despite challenges, integrating immunomics data within the One Health framework significantly enhances our strategies and responses to zoonotic diseases and pandemic threats, marking a crucial direction for future public health breakthroughs.