文献类型：期刊文献

中文题名：肿瘤坏死因子α在肝细胞癌发生发展中的作用

英文题名：The role of tumor necrosis factor-αin the development and progression of hepatocellular carcinoma

作者：朱玲玲[1,2];张亚妮[1,2];史婷婷[1,2];伍杨[1,2];高春[1];于晓辉[1];何昱静[1];张久聪[1]

第一作者：朱玲玲

机构：[1]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050;[2]甘肃中医药大学第一临床医学院,兰州730000

第一机构：中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050

年份：2024

卷号：40

期号：11

起止页码：2320

中文期刊名：临床肝胆病杂志

外文期刊名：Journal of Clinical Hepatology

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；

基金：中央高校优秀青年团队培育项目(31920220065);甘肃省卫生健康行业科研计划项目(GSWSKY2022-76);甘肃省科技计划项目(23JRRA1673)。

语种：中文

中文关键词：癌,肝细胞;肿瘤坏死因子α;信号传导;分子靶向治疗

外文关键词：Carcinoma,Hepatocellular;Tumor Necrosis Factor-alpha;Signal Transduction;Molecular Targeted Therapy

摘要：肿瘤坏死因子α(TNF-α)通过TNF受体介导的信号通路,参与调节肝细胞癌(HCC)细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时,TNF-α还可发挥诱导HCC细胞凋亡的作用。部分TNF-α抑制剂已被证实可抑制HCC进展,延长生存时间。目前,TNF-α在HCC中的潜在作用机制尚未完全阐明,探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点。本文总结TNF-α在HCC中作用机制的最新研究进展,并介绍以TNF-α为靶点治疗HCC的可能性,以期为HCC的防治和药物研发提供理论依据及参考。
Tumor necrosis factor-α(TNF-α)is involved in the regulation of multiple biological processes such as the proliferation,invasion,migration,and chemotherapy resistance of hepatocellular carcinoma(HCC)cells through TNF receptor-mediated signaling pathways.At the same time,TNF-αalso plays a role in inducing the apoptosis of HCC cells.Some TNF-αinhibitors have been shown to inhibit the progression of HCC and prolong survival time.At present,the potential mechanism of action of TNF-αin HCC remains unclear,and exploration of the interaction between TNF-αand HCC can help to determine the potential therapeutic targets for HCC.This article summarizes the latest research advances in the mechanism of action of TNF-αin HCC and introduces the possibility of targeting TNF-αas a treatment method for HCC,in order to provide a theoretical basis for the prevention and treatment of liver cancer and drug research and development.