文献类型：期刊文献

英文题名：DTNPD: A comprehensive database of drugs and targets for neurological and psychiatric disorders

作者：Luo, Ding[1]; Tong, Zhuohao[2]; Wen, Lu[2]; Bai, Mingze[2]; Jin, Xiaojie[3]; Liu, Zerong[4,5]; Li, Yinghong[2]; Xue, Weiwei[1]

第一作者：Luo, Ding

机构：[1] School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China; [2] Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China; [3] College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [4] Central Nervous System Drug Key Laboratory of Sichuan Province, Sichuan Credit Pharmaceutical Co. Ltd., Sichuan, 646100, China; [5] Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China

第一机构：School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

通信机构：[2]Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China

年份：2024

卷号：175

外文期刊名：Computers in Biology and Medicine

收录：EI(收录号：20241816021992);Scopus(收录号：2-s2.0-85191788379)

语种：英文

外文关键词：Neurology

摘要：In response to the shortcomings in data quality and coverage for neurological and psychiatric disorders (NPDs) in existing comprehensive databases, this paper introduces the DTNPD database, specifically designed for NPDs. DTNPD contains detailed information on 30 NPDs types, 1847 drugs, 514 drug targets, 64 drug combinations, and 61 potential target combinations, forming a network with 2389 drug-target associations. The database is user-friendly, offering open access and downloadable data, which is crucial for network pharmacology studies. The key strength of DTNPD lies in its robust networks of drug and target combinations, as well as drug-target networks, facilitating research and development in the field of NPDs. The development of the DTNPD database marks a significant milestone in understanding and treating NPDs. For accessing the DTNPD database, the primary URL is http://dtnpd.cnsdrug.com, complemented by a mirror site available at http://dtnpd.lyhbio.com. ? 2024