文献类型：期刊文献

中文题名：细胞焦亡在哮喘气道上皮屏障损伤中的作用机制研究进展

英文题名：Research progress on the mechanism of pyroptosis in airway epithelial barrier injury in asthma

作者：王金霞[1];雷丰丰[2]

第一作者：王金霞

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省人民医院呼吸与危重症医学科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：42

期号：3

起止页码：218

中文期刊名：中华劳动卫生职业病杂志

外文期刊名：Chinese Journal of Industrial Hygiene and Occupational Diseases

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD_E2023_2024】；PubMed;

基金：国家自然科学基金项目(41961016)。

语种：中文

中文关键词：哮喘;细胞焦亡;气道上皮屏障;损伤

外文关键词：Asthma;Pyroptosis;Airway epithelial barrier;Injury

摘要：细胞焦亡是一种由活化的半胱氨酸天冬氨酸蛋白酶切割Gasdermin家族蛋白介导的新型程序性细胞死亡形式, 其在控制急慢性疾病中发挥重要作用。哮喘是一种不同程度气流阻塞的慢性炎症性气道疾病。气道上皮屏障在启动宿主防御和控制免疫反应方面发挥着重要作用。研究表明, 细胞焦亡参与哮喘气道上皮屏障功能损伤及免疫调节异常。本文综述细胞焦亡在多种环境暴露因素参与哮喘气道上皮屏障损伤的调控机制, 为靶向治疗哮喘提供参考。
Pyroptosis is a novel form of programmed cell death mediated by cleavage of Gasdermin family proteins by activated caspases,which plays an important role in the control of acute and chronic diseases.Asthma is a chronic inflammatory airway disease with varying degrees of airflow obstruction.The airway epithelial barrier plays an important role in initiating host defenses and controlling immune responses.Accumulating evidence suggests that pyroptosis is involved in the impairment of airway epithelial barrier function and abnormal immune regulation in asthma.This article aims to review the latest regulatory mechanism of pyroptosis involved in airway epithelial barrier injury in asthma under various environmental exposure factors,and to provide a new method for targeted therapy of asthma.