文献类型：期刊文献

英文题名：Therapeutic potential of Astragalus membranaceus-Pueraria lobata decoction for the treatment of chemotherapy bowel injury

作者：Wang, Yixuan[1];Qin, Yujie[1];Kang, Qian[2];Wang, Huinan[2];Zhou, Shihong[1];Wu, Yifan[1];Liu, Yongqi[3,4];Su, Yun[2,3];Guo, Yaqiong[5];Xiu, Minghui[1,4];He, Jianzheng[4,5,6]

第一作者：王怡潇;王渊学;王雅欣

通信作者：Xiu, MH[1];He, JZ[1]

机构：[1]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent Tre, Lanzhou, Peoples R China;[4]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China;[5]Second Prov Peoples Hosp Gansu, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China.

年份：2024

卷号：38

期号：19

外文期刊名：FASEB JOURNAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001331367200001)】；

基金：This work was supported by the Gansu Natural Science Foundation (No. 23JRRA1202), National Natural Science Foundation of China (Nos. 82104562 and 82360896), Gansu Provincial Department of Education Innovation Ability Enhancement Project (No. 2023A-086), Gansu Provincial Department of Education (No. 2023CXZX-769). We are grateful to members of Xiu and He laboratory for useful comments on the manuscript.

语种：英文

外文关键词：Astragalus membranaceus; chemotherapy; Drosophila melanogaster; intestinal mucositis; molecular mechanism; Pueraria lobata decoction

摘要：Intestinal mucositis (IM) is one of the most serious side effects of the chemotherapeutic agent irinotecan (CPT-11). Astragalus membranaceus-Pueraria lobata decoction is from the ancient medical book Zhengzhihuibu, has been reported to be used for the treatment of diabetes and hypertension. However, the beneficial effect and mechanism of AP on chemotherapy intestinal mucositis (CIM) remain largely unknown. This study aimed to investigate the efficacy and mechanism of Astragalus membranaceus-Pueraria lobata decoction (AP) in treating CIM. The beneficial effect and mechanism of AP on chemotherapy intestinal mucositis (CIM) were detected using Drosophila model, and combination with RT qPCR, transcriptomics. AP supplementation could significantly alleviate the CPT-11-induced body injury in Drosophila, such as increasing the survival rate, recovering the impaired digestion, improving the movement, and repairing the reproduction and developmental processes. Administration of AP remarkably alleviated the IM caused by CPT-11, including inhibiting the excretion, repairing the intestinal atrophy, improving the acid-base homeostasis imbalance, and inhibiting the disruption of intestinal structure. Mechanistic studies revealed that the protective role of AP against CPT-11 induced intestinal injury was regulated mainly by inhibiting immune-related Toll and Imd pathways, and enhancing the antioxidant capacity. Taken together, these results suggest that AP may be a novel agent to relieve CIM.