文献类型：期刊文献

英文题名：The role of exosomes in ankylosing spondylitis: from biological features and functional cargo to clinical applications

作者：Yuan, Han-ying[1];Xu, Jia[1];Zhang, You-yu[2];Xi, Xuan[1];Pan, Heng[1];Zhao, Shu-jing[1];Li, Kai-xu[1];Li, De-hong[3];Lu, Yan[2]

第一作者：Yuan, Han-ying

通信作者：Lu, Y[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Peoples R China;[3]Gansu Prov Peoples Hosp, Blood Transfus Dept, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Peoples R China.

年份：2026

卷号：13

外文期刊名：FRONTIERS IN MOLECULAR BIOSCIENCES

收录：;Scopus(收录号：2-s2.0-105031622435);WOS:【SCI-EXPANDED(收录号:WOS:001703136500001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the Gansu Science and Technology Plan Project (Joint Research Fund-25JRRA1197), the Graduate Innovation and Entrepreneurship Fund of Gansu University of Chinese Medicine the grant number (NO.2026CXCY-180), Gansu Provincial Clinical Research Center for Laboratory Medicine (21JR7RA676).

语种：英文

外文关键词：ankylosing spondylitis; biomarkers; exosomes; immune inflammation; microRNA

摘要：Exosomes are small extracellular vesicles secreted by nearly all cell types and widely distributed in body fluids. They not only mediate intercellular material transfer but also play an important role in the regulation of immune pathways. Given their diverse biological functions, studies investigating the regulatory roles of exosomes in ankylosing spondylitis (AS) are receiving increasing attention. The functions of exosomes in AS largely depend on their bioactive cargo, including microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), proteins, and other molecules. In addition, exosome-induced intercellular communication and modulation of immune regulatory pathways are also critical. Recent studies have shown that exosomal crosstalk mechanisms may affect major AS-related pathways, such as immune responses, inflammatory signaling, and bone metabolism balance. This review summarizes the biological characteristics of exosomes and advances in their functional cargos in AS regulation. More animal and clinical studies are needed to explore the role of exosomes in AS. The ongoing development of sequencing technologies and biotechnology indicates that exosomes hold potential as diagnostic biomarkers for AS and provide new insights into its diagnosis and treatment.