文献类型：期刊文献

中文题名：H型血管内皮细胞铁死亡对骨稳态影响及相关机制的研究

英文题名：Study on the effect of ferroptosis of H-type vascular endothelial cells on bone homeostasis and related mechanisms

作者：樊佳煊[1];曹林忠[1,2]

第一作者：樊佳煊

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：10

起止页码：1449

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金(82160859);兰州市科技局项目(2022-3-23)。

语种：中文

中文关键词：H型血管;内皮细胞;Nrf2/GPX4信号;铁死亡;骨稳态

外文关键词：H-type vascular;endothelial cells;Nrf2/GPX4 signal;ferroptosis;bone homeostasis

摘要：H型血管形成与细胞铁死亡作为影响骨稳态的潜在机制,其相互关系在血管生成、骨形成方面逐渐受到关注。H型血管作为血小板-内皮细胞黏附分子(CD_(3)1)、内皮粘蛋白(EMCN)高表达的特殊血管结构,在新骨形成中发挥成血管-成骨耦合作用,促进缺损部位的骨再生;铁死亡是由细胞铁依赖性脂质过氧化物累积驱动的新型细胞死亡方式。近年来内皮细胞(endothelial cells, ECs)铁死亡在相关骨代谢疾病防治中成为研究热点,且相关机制相对成熟,而H型血管ECs铁死亡对骨稳态的研究仍处于初步阶段,因此该综述详细探讨了H型血管ECs铁死亡在血管生成、骨形成方面的作用,有望为深入理解骨稳态提供新的视角,并为开发新的治疗策略提供理论依据。
As a potential mechanism affecting bone homeostasis,the relationship between H-type angiogenesis and cell iron death has received increasing attention in the aspects of angiogenesis and bone formation.As a special vascular structure with high expression of platelet-endothelial cell adhesion molecule(CD_(3)1)and endothelial mucin(EMCN),H-type vessels play a coupling role in angiogenesis and osteogenesis during new bone formation,and promote bone regeneration at the site of bone defect.Iron death is a novel cell death mode driven by the accumulation of iron-dependent lipid peroxides.In recent years,iron death of endothelial cells(ECs)has become a hot research topic in the prevention and treatment of related bone metabolic diseases,and the related mechanism is relatively mature,while the research on the effect of iron death of H-type vascular ECs on bone homeostasis is still preliminary.Therefore,this review discussed in detail the role of iron death of H-type vascular ECs on angiogenesis and bone formation.It is expected to provide a new perspective for the in-depth understanding of bone homeostasis and provide a theoretical basis for the development of new treatment strategies.