文献类型：期刊文献

英文题名：Clinical evidence of acupuncture for luteinized unruptured follicle syndrome: a systematic review and meta-analysis of randomized controlled trials

作者：Zhang, Ruifang[1];Lin, Guangyao[2];Wang, Wei[1]

第一作者：张瑞芳

通信作者：Wang, W[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Dept Gynecol & Obstet, Lanzhou, Gansu, Peoples R China;[2]Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynaecol, Beijing, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Gynecol & Obstet, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001570781100001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. Gansu Provincial Regional Center for Traditional Chinese Medicine in Women's and Children's Health (grant numbers: 002115003-2101704).

语种：英文

外文关键词：acupuncture; infertility; luteinized unruptured follicle syndrome; ovulatory disorders; meta-analysis

摘要：Objective: This study aimed to systematically assess the efficacy of acupuncture in women with luteinized unruptured follicle syndrome (LUFS) based on existing randomized controlled trials (RCTs). Methods: A search of eight databases and one clinical trial database was conducted on May 3, 2025, to identify relevant RCTs examining the benefits of acupuncture for LUFS. The clinical outcomes of interest included two primary outcomes and five secondary outcomes. Forest plots were used to illustrate the pooled results, and sensitivity analyses were performed to verify the robustness of the evidence. Subgroup analysis was conducted to investigate whether the effect of acupuncture on the primary outcomes was related to the number of acupoints used per treatment. In addition, Begg's and Egger's tests were conducted to quantitatively examine publication bias among the studies. Results: A total of 15 RCTs from China involving 1,030 participants with LUFS were included. According to the pooled results, acupuncture intervention effectively increased the ovulation rate by 25% [risk difference (RD) = 0.25, 95%CI = 0.21-0.30, p < 0.00001] and the pregnancy rate by 22% (RD = 0.22, 95%CI = 0.16-0.28, p < 0.00001) compared with the control group. Moreover, acupuncture treatment was more conducive to improving the luteinizing hormone levels [mean difference (MD) = 3.76, 95%CI = 2.27-5.25, p < 0.00001], the estradiol levels [standardized MD (SMD) = 0.47, 95%CI = 0.31-0.63, p < 0.00001], the progesterone levels (MD = 1.50, 95%CI = 1.09-1.91, p < 0.00001), the resistance index (MD = -0.07, 95%CI = -0.09 to -0.05, p < 0.00001), and the pulsatility index (MD = -0.10, 95%CI = -0.15 to -0.06, p < 0.00001) of the ovarian artery. Subgroup analysis indicated a higher ovulation rate with stimulation of more than six acupoints (28%) compared with six or fewer acupoints (19%); however, there was no notable association between the number of acupoints and the pregnancy rate (22% vs. 23%). Furthermore, sensitivity analyses confirmed the robustness of the results, while both Begg's and Egger's tests indicated no significant publication bias across studies. Conclusions: This pooled evidence from Chinese RCTs reveals that acupuncture is a promising complementary therapy for LUFS. However, these findings might not be generalizable outside China, and most trials exhibited deficient methodological reporting. Therefore, further research studies with more rigorous designs and larger sample sizes are needed to confirm the efficacy of acupuncture for LUFS. Systematic review registration: www.crd.york.ac.uk, identifier CRD420251062225.