文献类型：期刊文献

英文题名：Research progress in the application of proteomics technology in brain injury

作者：Liu, Wenhu[1];Wen, Zhaomeng[1];Shi, Yuwei[1];Bao, Juan[2];Ma, Shaobo[2];Liang, Jin[2]

第一作者：刘文华

通信作者：Liang, J[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou City, Peoples R China;[2]Gansu Prov Hosp, Dept Neurosurg, Lanzhou City, Gansu Province, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Neurosurg, Lanzhou City, Gansu Province, Peoples R China.

年份：2024

卷号：38

期号：3

外文期刊名：BIOMEDICAL CHROMATOGRAPHY

收录：;EI(收录号：20234915143321);Scopus(收录号：2-s2.0-85178028541);WOS:【SCI-EXPANDED(收录号:WOS:001118120900001)】；

基金：No Statement Available

语种：英文

外文关键词：brain injury; diagnosis; expectation; prognosis; proteomics

摘要：The aim of this article is to review the application progress of proteomics technology in brain injury research in recent years, point out the current problems that need to be overcome, and explore the application prospects of proteomics analysis in brain injury. This study also aims to retrieve all literature on brain injury and proteomics and summarize it. Through searching and screening, the widespread application of proteomics technology in the treatment of traumatic brain injury (TBI) and the use of a large number of TBI biomarkers were discovered. The pathways mediated by some biomarkers and the physiological and pathological mechanisms of occurrence were elucidated. The current classification of brain injury is mainly based on subjective evaluation of clinical symptoms, combined with objective imaging. However, its practical value is often limited when applied to prognosis evaluation in brain injury. Proteomics technology can make up for this deficiency and provide a reference for the prevention and treatment of brain injury.