文献类型：期刊文献

英文题名：Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism

作者：Zhang, Yugui[1,2];Li, Yuefeng[1,2,4];Bian, Tiantian[1,2];Sun, Yujing[1,2];Zhang, Zhuanhong[1,2];Liu, Ting[1,2];Gao, Feiyun[1,2];Wang, Yanjun[1,2];Cao, Rui[1,2];Xin, Erdan[1,2];Yan, Xingke[3,5]

第一作者：张永刚

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Engn Res Ctr Chinese Med Pharmaceut Proc Gansu, Key Lab Stand & Qual Chinese Med Res Gansu, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Peoples R China;[5]35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), 35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China.

年份：2023

卷号：108

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;Scopus(收录号：2-s2.0-85170052082);WOS:【SCI-EXPANDED(收录号:WOS:001080053000001)】；

基金：The research was funded by various sources, including the Chinese Medicine Pharmaceutical Process Engineering Research Center Open Fund of Gansu (ZYGY202003), the National Natural Science Foundation of China (81960713 and 82160750), the Gansu Provincial Education Department Industrial Support Plan Project (2021CYZC21), the Traditional Chinese medicine processing technology inheritance base in Gansu province (Gan Wei Traditional Chinese Medicine Letter No. 288 [2022]), and the Gansu Provincial Department of Science and Technology-Science and Technology Plan (Innovation Base and Talent Plan) Basic Research Innovation Group Project (21JR7RA569).

语种：英文

外文关键词：Hedysari Radix Praeparata Cum Melle; Colitis-associated colorectal cancer; Gut microbiota; Metabolites; Intestinal barrier function; Mechanism

摘要：Hedysari Radix Praeparata Cum Melle (HR) has a potential to decrease the risk of chronic colorectal inflammation developing to colorectal cancer. Our study found that HR attenuated the pathological state, improved survival rate, diminished K-Ras, IL-1 beta, IL-6 and TNF-alpha levels, and increased the levels of the intestinal barrier function proteins including claudin-1, E-cadherin and mucin-2 in colitis-associated colorectal cancer (CAC) mice. Moreover, HR maintains intestinal flora homeostasis and fecal metabolic profiling through balancing the abundances of bacteroides prevotellaceae_UCG-001, staphylococcus, turicibacter, and rikenella to further regulates the galactose metabolism. The spearman correlation analysis showed that the intestinal barrier function proteins, gut microbiota and differential metabolism were significantly correlated with each other. This study confirmed a potential mechanism that HR alleviates CAC by diminishing symptoms and the inflammation, thereby improving the function of intestinal barrier and preserving intestinal flora homeostasis and fecal metabolic profiling.