文献类型：期刊文献

英文题名：Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review)

作者：Yun, Heng[1];Dong, Fangde[1];Wei, Xiaoqin[2];Yan, Xinyong[3];Zhang, Ronglong[1];Zhang, Xiuyu[4];Wang, Yulin[1]

第一作者：Yun, Heng

通信作者：Wang, YL[1];Zhang, XY[2]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Gen Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China;[2]Second Peoples Hosp Baiyin, Dept Pain, Baiyin 730900, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Proctol, Baiyin 730900, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Gastroenterol, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Gen Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Gastroenterol, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：53

期号：1

外文期刊名：ONCOLOGY REPORTS

收录：;Scopus(收录号：2-s2.0-85210915536);WOS:【SCI-EXPANDED(收录号:WOS:001372201200001)】；

基金：Not applicable.

语种：英文

外文关键词：gastric cancer; tumor microenvironment; cancer-associated fibroblasts; extracellular matrix; immune cell; therapeutic resistance

摘要：Gastric cancer (GC) is characterized by a complex and heterogeneous tumor microenvironment (TME) that significantly influences disease progression and treatment outcomes. The tumor stroma, which is composed of a variety of cell types such as cancer-associated fibroblasts, immune cells and vascular components, displays significant spatial and temporal diversity. These stromal elements engage in dynamic crosstalk with cancer cells, shaping their proliferative, invasive and metastatic potential. Furthermore, the TME is instrumental in facilitating resistance to traditional chemotherapy, specific treatments and immunotherapy strategies. Understanding the underlying mechanisms by which the GC microenvironment evolves and supports tumor growth and therapeutic resistance is critical for developing effective treatment strategies. The present review explores the latest progress in understanding the intricate interactions between cancer cells and their immediate environment in GC, highlighting the implications for disease pathogenesis and therapeutic interventions.