文献类型：期刊文献

英文题名：Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)

作者：Shao, Li-Hua[1];Zhu, Li[2];Wang, Meng[1];Ning, Yue[1];Chen, Feng-Qin[2];Gao, Xia-Qing[1];Yang, Chun-Ting[1];Wang, Hong-Wei[3];Li, Hai-Long[1,4]

第一作者：Shao, Li-Hua

通信作者：Li, HL[1];Wang, HW[2]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Dept Internal Med, 35 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Hubei Minzu Univ, Minda Hosp, Emergency Dept, Enshi 445000, Hubei, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Clin Lab, 732 West Jiayuguan Rd, Lanzhou 730050, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Geriatr, Lanzhou 730050, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Dept Internal Med, 35 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Clin Lab, 732 West Jiayuguan Rd, Lanzhou 730050, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：52

期号：2

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-85164231225);WOS:【SCI-EXPANDED(收录号:WOS:001033944300001)】；

语种：英文

外文关键词：tumor multidrug resistance; high mobility group box 1; apoptosis and autophagy; pyroptosis; ferroptosis; non-coding RNA; traditional Chinese medicine; nanoparticles

摘要：Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double-edged sword' that plays both pro- and anti-tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non-coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1-mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target.