文献类型：期刊文献

英文题名：Targeted regulatory strategies for VCAM-1 in multisystem diseases

作者：Peng, Ruirong[1,2];Zhang, Yu[1,2];He, Zhenyu[1,2];Pang, Yueling[1,2];Ma, Huanhuan[1,2];Fang, Ming[1,2];Ding, Xiaoshan[1,2];Wang, Yanan[1,2];Du, Zhihong[1,2];Kong, Fanming[1,2];Chen, Liping[1,2];Liu, Yongqi[1,2,3];Li, Ling[1,2,3];Li, Jiawei[1,2,3]

第一作者：Peng, Ruirong

通信作者：Liu, YQ[1];Li, L[1];Li, JW[1]

机构：[1]Gansu Univ Chinese Med, Key Lab Mol Med & Chinese Med Prevent & Treatment, Gansu Univ, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab Dun Huang Med & Transformat, Minist Educ Peoples Republ China, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou 730050, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou 730050, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2025

卷号：15

外文期刊名：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS

收录：WOS:【ESCI(收录号:WOS:001588543000001)】；

基金：This study was supported by the National Natural Science Foundation of China (No. 82160896); Research Project of Gansu Provincial Administration of Traditional Chinese Medicine (GZKP-2022-38); Gansu University of Chinese Medicine 2024 College Students' Innovation and Entrepreneurship Training Program Project (2023-14/19); Key Laboratory of Dunhuang Medicine, Ministry of Education Open Project (DHYX21-02).

语种：英文

外文关键词：VCAM-1; VLA-4; Tumor; Mechanism of action; Effective compounds of traditional Chinese medicine; Traditional Chinese medicine compound

摘要：Systemic diseases are conditions caused by multiple factors (such as immune disorders, inflammation, tumors, etc.) that affect multiple organs, tissues, or systems throughout the body. These diseases are typically characterized by complex pathological states and diverse clinical symptoms. Vascular cell adhesion molecule-1 (VCAM-1) is a multifunctional transmembrane protein that plays a key role in various pathological processes, including inflammation, immune responses, and tumor progression, by mediating immune cell adhesion, regulating the tumor microenvironment, and facilitating signal transduction. This article aims to review the mechanistic roles of VCAM-1 in systemic diseases affecting the circulatory, respiratory, and digestive systems, as well as the association between VCAM-1 and tumor characteristics. Additionally, it discusses targeted therapeutic drugs (including traditional Chinese medicine and Western medicine) that regulate VCAM-1 for disease treatment, providing a theoretical basis for clinical research.