文献类型：期刊文献

英文题名：The effect of pulmonary rehabilitation for post-acute sequelae of SARS-CoV-2 infection in patients: a systematic review and meta-analysis

作者：Yue, Yinghua[1];Han, Xinyi[1];Chen, Qiming[1];Dai, Lirong[2];Ai, Qingjuan[1];Zhang, Zhigang[1];Ma, Fangli[1];Gao, Jing[3,4,5,6,7]

第一作者：Yue, Yinghua

通信作者：Zhang, ZG[1];Ma, FL[1];Gao, J[2];Gao, J[3];Gao, J[4];Gao, J[5];Gao, J[6]

机构：[1]Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[3]Karolinska Inst, Dept Med Solna, Div Immunol & Resp Med, Stockholm, Sweden;[4]Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden;[5]Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden;[6]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[7]Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China;[2]corresponding author), Karolinska Inst, Dept Med Solna, Div Immunol & Resp Med, Stockholm, Sweden;[3]corresponding author), Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden;[4]corresponding author), Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden;[5]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[6]corresponding author), Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China.

年份：2025

卷号：6

外文期刊名：FRONTIERS IN REHABILITATION SCIENCES

收录：Scopus(收录号：2-s2.0-105021877406);WOS:【ESCI(收录号:WOS:001615907400001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Grant no. 82560660), the Scientists Fund of the First Hospital of Lanzhou University, China (Grant no. ldyyyn2021-132), the Gansu Provincial Natural Science Foundation (Grant no.24JRRA1073), and WU JIEPING MEDICAL FOUNDATION (Grant no.6750.2022-02-8). Jing Gao was supported by Karolinska Institutet Research Foundation Grants (2022-02329) and the Scientists Fund of the Gansu Provincial Hospital of China (Grant no. 2024KYQDJ-A-2; no. 24GSSYA-9). The funder has no role in the data collection, data analysis, preparation of manuscript and decision to submission.

语种：英文

外文关键词：pulmonary rehabilitation; post-acute sequelae of SARS-CoV-2 infection; telerehabilitation; fatigue; exercise capacity

摘要：Background: Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID, are characterized by persistent symptoms such as fatigue, dyspnea, and reduced functional capacity. Pulmonary rehabilitation (PR) is recommended for chronic respiratory conditions, but its effectiveness in PASC, particularly across different delivery modes, remains uncertain. Objective: To assess the impact of PR, including telerehabilitation and in-person modalities, on physical function, dyspnea, pulmonary function, fatigue, and quality of life in patients with PASC. Methods: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science from inception to March 25 for controlled clinical trials assessing the effects of PR in PASC patients. Two independent reviewers performed study selection and data extraction. The risk of bias was assessed using the Cochrane Risk of Bias Tool, and data were analyzed using Review Manager (RevMan) 5.4.1. Effect sizes were reported as mean differences (MD) or standardized mean differences (SMD) with 95% confidence intervals (CI). Results: Ten randomized controlled trials involving 673 participants were included. Most studies were judged to have a moderate risk of bias. Compared with usual care, PR significantly improved six-minute walk distance (MD: 76.85 meters; 95% CI: 57.35-96.36; p < 0.001), maximal inspiratory pressure (MD: 17.63 cmH(2)O; 95% CI: 4.50-30.76; p = 0.009), fatigue (SMD: -1.15; 95% CI: -1.83 to -0.48; p < 0.001), and quality of life (SMD: 1.73; 95% CI: 0.56-2.91; p = 0.004). No statistically significant improvement was found for dyspnea (MD: -0.41; 95% CI: -1.51 to -0.68; p = 0.46). Subgroup analyses showed no significant differences between telerehabilitation and in-person PR across all outcomes, including exercise capacity (p = 0.84), dyspnea (p = 0.86), fatigue (p = 0.93), and quality of life (p = 0.44). Conclusions: PR improves physical and functional outcomes in patients with PASC. Telerehabilitation offers a clinically equivalent alternative to in-person PR, supporting its broader implementation.