文献类型：期刊文献

英文题名：The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review

作者：Liu, Dongling[1];Wen, Linlin[2,3];Wang, Zhandong[2];Hai, Yang[4];Yang, Dan[2];Zhang, Yanying[4,5];Bai, Min[5];Song, Bing[4,5];Wang, Yongfeng[5]

第一作者：刘东玲

通信作者：Wang, YF[1]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[3]Cty Peoples Hosp, Pingliang, Peoples R China;[4]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou, Peoples R China;[5]Gansu Prov Lab Anim Ind Technol Ctr, Gansu Prov Engn Lab Res & Promot Qual Standardizat, Prov Key Lab Pharmaceut Chem & Qual Res Coll & Uni, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Lab Anim Ind Technol Ctr, Gansu Prov Engn Lab Res & Promot Qual Standardizat, Prov Key Lab Pharmaceut Chem & Qual Res Coll & Uni, Lanzhou, Peoples R China.

年份：2022

卷号：9

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85134492191);WOS:【SCI-EXPANDED(收录号:WOS:000831610500001)】；

基金：This project was supported by the National Natural Science Foundation of China (grant numbers 82160871, 81760828, and 82074419).

语种：英文

外文关键词：acute pancreatitis; lung injury; intestinal injury; inflammation response; oxidative stress; endocrine disorders

摘要：Acute pancreatitis (AP), as a common cause of clinical acute abdomen, often leads to multi-organ damage. In the process of severe AP, the lungs and intestines are the most easily affected organs aside the pancreas. These organ damages occur in succession. Notably, lung and intestinal injuries are closely linked. Damage to ML, which transports immune cells, intestinal fluid, chyle, and toxic components (including toxins, trypsin, and activated cytokines to the systemic circulation in AP) may be connected to AP. This process can lead to the pathological changes of hyperosmotic edema of the lung, an increase in alveolar fluid level, destruction of the intestinal mucosal structure, and impairment of intestinal mucosal permeability. The underlying mechanisms of the correlation between lung and intestinal injuries are inflammatory response, oxidative stress, and endocrine hormone secretion disorders. The main signaling pathways of lung and intestinal injuries are TNF-alpha, HMGB1-mediated inflammation amplification effect of NF-kappa B signal pathway, Nrf2/ARE oxidative stress response signaling pathway, and IL-6-mediated JAK2/STAT3 signaling pathway. These pathways exert anti-inflammatory response and anti-oxidative stress, inhibit cell proliferation, and promote apoptosis. The interaction is consistent with the traditional Chinese medicine theory of the lung being connected with the large intestine (fei yu da chang xiang biao li in Chinese). This review sought to explore intersecting mechanisms of lung and intestinal injuries in AP to develop new treatment strategies.