文献类型：期刊文献

英文题名：Plant-Derived Extracellular Vesicles for Nanomedicine in Cardiopulmonary Diseases: A Narrative Review

作者：Zhang, Juan-Juan[1];Huang, Yu-Qian[2];Liu, Xuekai[3];Xie, Ping[1,3,4,5,6]

第一作者：张晶晶;张锦锦;张静婧;张建军

通信作者：Xie, P[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Chengdu Second Peoples Hosp, Ctr Med Cosmetol, Chengdu, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[4]Gansu Prov Hosp, Dept Cardiovasc Med, Lanzhou, Peoples R China;[5]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[6]Ctr Natl Clin Res Ctr Cardiovasc Dis, Construction Unit Branch, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：21

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;Scopus(收录号：2-s2.0-105040577344);WOS:【SCI-EXPANDED(收录号:WOS:001782165700001)】；

基金：Funding Gansu Provincial Joint Research Fund (No. 24JRRA886) . Graduate Innovation and Entrepreneurship Fund Project of Gansu University of Chinese Medicine (No. 2026CXCY-017) .

语种：英文

外文关键词：plant-derived extracellular vesicles; nanomedicine; drug delivery; cardiovascular diseases; respiratory system diseases

摘要：This narrative review summarizes research progress on plant-derived extracellular vesicles (PEVs) for nanomedicine in cardiopulmonary system diseases, based on key literature covering isolation, engineering, and disease mechanisms. PEVs possess high biocompatibility, low immunogenicity, broad source availability, and scalability. Their bioactive cargo (proteins, nucleic acids, lipids, secondary metabolites) regulates inflammation, oxidative stress, apoptosis, and fibrosis. This review systematically discusses PEV characteristics, large-scale isolation, and engineering approaches, with a focus on multi-target and cell-specific mechanisms in atherosclerosis, myocardial infarction, COPD, and pulmonary fibrosis. Although challenges in standardization, in vivo mechanisms, and translation remain, engineered PEVs hold promise as efficient and safe nanomedicines. The unique contribution of this review is to integrate PEV preparation and engineering with their disease-specific mechanisms, providing a coherent framework for future translational research in cardiopulmonary nanomedicine.