文献类型：期刊文献

中文题名：lncRNA对类风湿关节炎骨破坏的影响及机制探讨

英文题名：Effect of lncRNA on bone destruction in rheumatoid arthritis and its mechanism

作者：王丽琴[1];王钢[1];王佳[1];魏勇[1]

第一作者：王丽琴

机构：[1]甘肃中医药大学附属医院风湿骨病科,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2021

卷号：37

期号：20

起止页码：2535

中文期刊名：中国免疫学杂志

外文期刊名：Chinese Journal of Immunology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然基金项目(81860858);甘肃省中医药管理局科研项目(GZK-2019-34);甘肃中医药大学附属医院院内创新基金项目(gzfy-2018-01)。

语种：中文

中文关键词：长链非编码RNA;类风湿关节炎;骨破坏;机制探讨

外文关键词：Long non-coding RNA;Rheumatoid arthritis;Bone destruction;Mechanism discussion

摘要：类风湿关节炎(RA)是一种以持续性滑膜炎症和骨质流失导致关节骨侵蚀和畸形为特征的破坏性自身免疫性疾病,RA骨破坏是一种典型的骨代谢紊乱性疾病。近年长链非编码RNA(lncRNA)对骨代谢的影响及相关性研究备受关注。lncRNA是一类长度超过200 nt的转录产物,具有较长核苷酸链,可通过影响破骨细胞(OC)分化和成熟调节软骨、成骨分化和骨基质矿化,参与骨形成和骨吸收过程,从而调节骨代谢,维持骨稳态。因此,lncRNA有望成为RA骨破坏的生物标志物,为临床治疗提供新思路、新策略。
Rheumatoid arthritis(RA)was a destructive autoimmune disease characterized by persistent synovitis and bone loss leading to erosion and deformity of articular bone.RA bone destruction was a typical disorder of bone metabolism.In recent years,effects of long non-coding RNA(lncRNA)on bone metabolism and its correlation had attracted more and more attention.lncRNA was a kind of transcription product with a length of more than 200 nt and a long nucleotide chain,which could regulate bone metabolism and maintain bone homeostasis by regulating differentiation and maturation of osteoclasts(OC),regulating cartilage,osteogenic differ-entiation and mineralization of bone matrix,and participating in process of bone formation and bone resorption.Therefore,lncRNA was expected to become a new target for treatment of RA and provide new ideas and strategies for clinical treatment.