文献类型：期刊文献

中文题名：小儿开胃增食合剂对小儿厌食症大鼠神经肽Y的影响

英文题名：The effect of Xiao'erkaiweizengshi Mixture on the content of neural peptide Y inrats with infantile anorexia

作者：王继芳[1];吴丽萍[2];史正刚[1];王英龙[1];尚菁[1]

第一作者：王继芳

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院儿科,甘肃兰州730020

第一机构：甘肃中医药大学

年份：2016

卷号：24

期号：2

起止页码：92

中文期刊名：中国中西医结合消化杂志

外文期刊名：Chinese Journal of Integrated Traditional and Western Medicine on Digestion

收录：CSTPCD

基金：甘肃省高等学校基金科研项目(No:BH2012-015)

语种：中文

中文关键词：小儿开胃增食合剂;小儿厌食症;神经肽Y

外文关键词：Xiao＇erkaiweizengshi Mixture; infantile anorexia; NPY

摘要：[目的]探讨小儿开胃增食合剂对小儿厌食症幼龄大鼠下丘脑和外周血中神经肽Y(neural peptide Y,NPY)的影响。[方法]SD大鼠72只随机分为6组,每组各12只,采用病因模拟法建立小儿厌食症动物模型,分别对幼龄大鼠下丘脑和外周血中NPY含量进行检测。[结果]模型组与空白组、小儿开胃增食合剂中、高剂量组大鼠下丘脑和外周血中NPY含量比较,差异均有统计学意义(P<0.05、P<0.01);对照组与中、高剂量组下丘脑和外周血中NPY含量比较,差异有统计学意义(P<0.05、P<0.01);小剂量组与中、高剂量组下丘脑和外周血中NPY含量比较,差异有统计学意义(P<0.05、P<0.01)。[结论]小儿开胃增食合剂可明显改善小儿厌食症幼龄大鼠的食欲,提高下丘脑和外周血中NPY水平,且存在量效关系,这可能是该方治疗小儿厌食症的疗效机理之一。
[Objective]To study the effect of Xiao＇erkaiweizengshi Mixture on the content of neural peptide Y（NPY）in hypothalamic and peripheral blood of SD rats with infantile anorexia.[Methods]All 72 rats were randomized into 6group,12 rats in each group.The method of etiology simulation was used to set up animal model of infantile anorexia.NPY contents in hypothalamic and peripheral blood were measured respectively.[Results]Compared with model group,there was significant difference in the levels of NPY in hypothalamic and peripheral blood in blank group,high dosage and middle dosage group of Xiao＇erkaiweizengshi Mixture（P0.05,P0.01）.There was significant difference in the levels of NPY in hypothalamic and peripheral blood between control group and high and middle dosage groups of Xiao＇erkaiweizengshi Mixture（P0.05,P0.01）.There was significant difference in the levels of NPY in hypothalamic and peripheral blood between low dosage group and high and middle dosage groups of Xiao＇erkaiweizengshi Mixture（P0.05,P0.01）.[Conclusion]Xiao＇erkaiweizengshi Mixture can obviously increase food intake of rats and improve the content of NPY with a dose-dependent manner,which may be one of the important mechanisms in treating children anorexia syndrome.