文献类型：期刊文献

中文题名：间充质干细胞及外泌体对高原脑水肿的潜在作用机制研究进展

英文题名：Research progress on the potential mechanism of mesenchymal stem cells and exosomes in high altitude brain edema

作者：张研[1,3];雷胜男[2];张茜[1,2,3];哈小琴[4];马慧萍[5];孙海燕[1,3];周士燕[1,2]

第一作者：张研

机构：[1]中国人民解放军联勤保障部队第九四〇医院血液科,甘肃兰州730050;[2]西北民族大学,甘肃兰州730106;[3]甘肃中医药大学第一临床医学院,甘肃兰州730000;[4]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050;[5]中国人民解放军联勤保障部队第九四〇医院全军高原医学实验室,甘肃兰州730050

第一机构：中国人民解放军联勤保障部队第九四〇医院血液科,甘肃兰州730050

年份：2024

卷号：28

期号：2

起止页码：129

中文期刊名：实用临床医药杂志

外文期刊名：Journal of Clinical Medicine in Practice

收录：CSTPCD

基金：甘肃省卫生健康行业科研计划资助项目(GSWSKY2021-044);甘肃省科技计划项目自然科学基金项目(21JR1RA183);中央高校基本科研重大需求培育项目(31920220110)。

语种：中文

中文关键词：高原反应;高原性脑水肿;脑损伤;间充质干细胞;缺氧;防治

外文关键词：altitude stress;high altitude brain edema;brain injury;mesenchymal stem cells;hypoxia;prevent and treatment

摘要：近年来,短期、长期居住在高海拔地区的人数不断增加,超过8160万人生活在海拔≥2500米的地区,而中国常居高原者超过1000万,每年进入高原的人口超过2000万。独特的高原气候引发了一系列高原相关性疾病,其中高原脑水肿(HACE)是最严重的疾病之一,如果不及时进行适当治疗,患者可能会在24 h内因脑疝死亡。然而,HACE发展的确切机制尚不完全清楚,使得HACE的防和治具有挑战性。间充质干细胞(MSC)及间充质干细胞外泌体(MSC-Exos)具有修复受损组织和细胞、抗氧化应激、抑制炎症反应、调节自噬等作用,有可能成为防治HACE的新型药物。本文结合国内外相关文献阐述高原脑水肿发病机制及MSC、MSC-Exos在其中可能发挥的作用,为MSC、MSC-Exos防治HACE提供理论依据。
In recent years,the number of people living in short-term and long-term period in high-altitude has been continuously increasing,with over 81.6 million people living in areas with an altitude of≥2,500 meters.In China,there are over 10 million people who frequently reside at high altitudes,and over 20 million people enter the plateau every year.The unique plateau climate has triggered a series of plateau related diseases,among which high altitude cerebral edema(HACE)is one of the most serious diseases.If patients are not treated promptly and appropriately,they may die from cerebral hernia within 24 hours.However,the exact mechanism of the development of HACE is not fully understood,which makes the clinical prevention and treatment of HACE challenging.Mesenchymal stem cells(MSC)and their exosomes(MSC-Exos)have the ability to repair damaged tissues and cells,resist oxidative stress,inhibit inflammatory reactions,and regulate autophagy,which may potentially become new drugs for preventing and treating HACE.This article elucidated the pathogenesis of high altitude brain edema and the potential roles of MSC and MSC-Exos based on relevant literature at home and abroad,providing a theoretical basis for the prevention and treatment of HACE by MSC and MSC-Exos.