文献类型：期刊文献

英文题名：Implication of protein post translational modifications in gastric cancer

作者：Song, Houji[1];Zhang, Mingze[1];Guo, Chengwang[1];Guo, Xi[1];Ma, Yuqi[1];Ma, Yuntao[1,2]

第一作者：Song, Houji

通信作者：Ma, YT[1];Ma, YT[2]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：13

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85218183546);WOS:【SCI-EXPANDED(收录号:WOS:001423340200001)】；

基金：The authors thank all the members of Department of General Surgery of Gansu Provincial People's Hospital for the discussions.

语种：英文

外文关键词：gastric cancer; ubiquitination; phosphorylation; acetylation; glycosylation; methylation; lactylation; SUMOylation

摘要：Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. Emerging research has highlighted lactylation and glycosylation. The diverse realm of PTM and PTM crosstalk is linked to many critical signaling events involved in neoplastic transformation, carcinogenesis and metastasis. This review provides a comprehensive overview of the impact of PTM on the occurrence and progression of GC. Specifically, aberrant PTM have been shown to alter the proliferation, migration, and invasion capabilities of GC cells. Moreover, PTM are closely associated with resistance to chemotherapeutic agents in GC. Notably, this review also discusses the phenomenon of PTM crosstalk, highlighting the interactions among PTM and their roles in regulating signaling pathways and protein functions. Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions.