文献类型：期刊文献

英文题名：The ultimate microbial composition for correcting Th17/Treg cell imbalance and lipid metabolism disorders in osteoporosis

作者：An, Fangyu[3];Jia, Xueru[2];Shi, Yangyang[2];Xiao, Xiaolong[1];Yang, Fan[1];Su, Junchang[2];Peng, Xia[1];Geng, Guangqin[2];Yan, Chunlu[1]

第一作者：安方玉

通信作者：Yan, CL[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：144

外文期刊名：INTERNATIONAL IMMUNOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85209582373);WOS:【SCI-EXPANDED(收录号:WOS:001361800000001)】；

基金：This review get grants from the National Natural Science Foundation of China (No. 82060872) , the Scientific Research Program of Gansu Chinese Medicine Bure (No. GZKP-2023-39, No. GZKP-2023-63) , the Innovation Fund Project of University Teachers (No. 2024B-096) , and Technology Plan Project of Dingxi City (No. DX2024BY018) .

语种：英文

外文关键词：Intestinal microbiota; Immune regulation; Lipid metabolism; Osteoporosis

摘要：Osteoporosis is a systemic bone disease characterised by decreased bone mass and a deteriorated bone microstructure, leading to increased bone fragility and fracture risk. Disorders of the intestinal microbiota may be key inducers of osteoporosis. Furthermore, such disorders may contribute to osteoporosis by influencing immune function and lipid metabolism. Therefore, in this review, we aimed to summarise the molecular mechanisms through which the intestinal microbiota affect the onset and development of osteoporosis by regulating Th17/ Treg imbalance and lipid metabolism disorders. We also discussed the regulatory mechanisms underlying the effect of intestinal microbiota-related modulators on Th17/Treg imbalance and lipid metabolism disorders in osteoporosis, to explore new molecular targets for its treatment and provide a theoretical basis for clinical management.