文献类型：期刊文献

英文题名：Progress in the mechanism of acupuncture intervention on pain emotion and pain cognition mediated by limbic system

作者：Ma, Cui[1];Zou, Yichun[1];Ye, Yujuan[1];Cao, Mengqi[1];Yan, Xingke[1]

第一作者：马春;马程

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Acupuncture & Massage Coll, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Acupuncture & Massage Coll, Lanzhou 730000, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;

年份：2022

卷号：20

期号：6

起止页码：499

外文期刊名：JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE

收录：WOS:【ESCI(收录号:WOS:000903498100010)】；

基金：This work was supported by 2021 Scientific Planning Project of Gansu Province (2021 ??????????; No. 21JR1RA266); Project of National Natural Science Foundation of China (??????????, No. 81460744).

语种：英文

外文关键词：Acupuncture Therapy; Acupuncture Analgesia; Pain; Limbic System; Gyrus Cinguli; Amygdala; Hippocampus; Receptors; Opioid

摘要：Pain is a complex physiological and psychological activity, involving at least three dimensions, including pain sensation, pain emotion, and pain cognition. Acupuncture can clearly relieve the pain sensation of patients and improve pain emotion and pain cognition induced by pain; acupuncture participates in the multi-dimensional regulation of pain through brain regions of the limbic system such as anterior cingulate cortex (ACC), amygdala (AMY), and hippocampus. By analyzing relevant literature, it has been found that the regulation of acupuncture on pain emotion is mainly related to the activation of pertinent opioid receptors in the ACC, the decrease of the expression of extracellular signal-regulated kinase (ERK), and the promotion of the expression of glutamic acid (Glu) A1, metabotropic glutamate receptor-1 (mGluR1), and gamma-aminobutyric acid aminobutyric acid (GABA) B2 protein in the AMY. The regulation of acupuncture on pain cognition is mainly related to the elevation of the expression of protein kinase A (PKA) and phospho-p38 mitogen-activated protein kinase (phospho-p38 MAPK) and the inhibition of cyclic adenosine monophosphate (cAMP)/PKA/cAMP response element-binding protein (CREB) signaling pathway in the ACC.