文献类型：期刊文献

中文题名：基于文献数据挖掘的前列腺癌中医证候规律研究

英文题名：Study on Traditional Chinese Medicine Syndrome Regularity of Prostate Cancer Based on Literature Data Mining

作者：许晨璐[1];梁建庆[1,2];王佳华[1];董海玉[1];韩政阳[1];李斐[1]

第一作者：许晨璐

机构：[1]甘肃中医药大学基础医学院,甘肃兰州730000;[2]敦煌医学与转化教育部重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2023

卷号：32

期号：8

起止页码：107

中文期刊名：中国民族民间医药

外文期刊名：Chinese Journal of Ethnomedicine and Ethnopharmacy

基金：国家自然科学基金项目(No.81660767,No.82160929);2021年度甘肃省科技厅第十一批省级科技计划自然科学基金(自筹经费)项目(21JR11RA143);2021年度甘肃省教育厅青年博士基金项目(2021QB-077);敦煌医学与转化教育部重点实验室开放课题(No.DHYX18-08);甘肃省中医药研究中心开放课题(zyzx-2020-zx20)。

语种：中文

中文关键词：前列腺癌;证候;证素;症状/体征;数据挖掘

外文关键词：Prostate Cancer;TCM Syndromes;TCM Pattern Elements;Symptoms/Signs;Data Mining

摘要：目的:通过文献数据挖掘探讨前列腺癌中医证素及症状/体征分布规律,为辨证论治提供参考。方法:检索中国知网、万方、维普及中国生物医学文献数据库中前列腺癌中医证型、证素及症状/体征相关文献,建立数据库,运用SPSS Statistics 26.0和Gephi 0.9.2软件进行因子、聚类及复杂网络分析,挖掘前列腺癌患者的中医证候特点和分布规律。结果:前列腺癌证型分布以下焦湿热证多见,总体以虚证为主。证素分布显示病位多在肾、脾、肝及下焦,病理性质正虚邪实,正虚以气、阴、阳、血的亏虚为主,实以血瘀、湿、热、毒、痰为主。证素聚类分析结果分为7类:肾阳亏虚证、毒瘀互结证、脾气血两虚证、肝阴亏虚证、下焦湿热证、痰浊内阻证和气机郁滞证。症状/体征复杂网络分析核心症状/体征为尿频尿急、小便不利、神疲乏力、纳呆、腰膝酸软、腰痛、失眠、夜尿多、舌红、腹部胀痛、大便干燥、口干口渴、排尿疼痛、消瘦、畏寒肢冷。症状/体征因子及聚类分析最终聚为5类:气阴亏虚证、肾阳亏虚证、肾虚湿热证、气虚血瘀证、热毒内蕴证。结论:正虚邪实是前列腺癌变化发展的主要病机,肾阳亏虚证、气阴亏虚证、下焦湿热证、毒瘀互结证是前列腺癌的临床常见证型。
Objective To explore the distribution of TCM syndromes and symptoms/signs of prostate cancer by literature data mining,and to provide reference basis for syndrome differentiation and treatment.Method The literatures related to TCM syndrome types,syndrome elements and symptoms/signs of prostate cancer were retrieved from CNKI,Wanfang,VIP and Chinese Biomedical literature database,and the database was established.SPSS Statistics 26.0 and Gephi 0.9.2 software were used for factor,cluster and complex network analysis.Explore the TCM syndrome characteristics and distribution of prostate cancer patients.Results The syndrome type distribution of prostate cancer is mainly damp-heat syndrome of lower coke,and generally deficiency syndrome.The distribution of syndrome elements showed that the disease location was mostly in kidney,spleen,liver and lower coke.The pathological nature of positive deficiency was mainly deficiency of qi,Yin,Yang and blood,while the latter was mainly blood stasis,dampness,heat,poison and phlegm.The results of cluster analysis of syndrome elements were divided into 7 categories:deficiency of kidney-yang syndrome,combination of poison and stasis syndrome,deficiency of spleen-qi and blood syndrome,deficiency of liver-yin syndrome,damp-heat syndrome of lower jiao,obstruction of phlegm and turbidness,and stagnation of qi.Symptoms/Signs Complex network analysis Core symptoms/signs were frequent urination,urination difficulty,fatigue,lethargy,soreness in the waist and knees,lumbago,insomnia,nocturia,red tongue,abdominal distension,dry stool,dry mouth and thirst,painful urination,emaciation,chills and cold limbs.Symptoms/sign factors and cluster analysis finally clustered into five categories:Qi Yin deficiency syndrome,kidney Yang deficiency syndrome,kidney deficiency and heat syndrome,Qi deficiency and blood stasis syndrome,heat poison accumulation syndrome.Conclusion Positive deficiency and pathogenic solid are the main pathogenesis of prostate cancer.Kidney Yang deficiency syndrome,Qi Yin deficiency syndrome,lower coke dampness and heat syndrome,poison and blood stasis mutual junction syndrome are the common clinical syndrome of prostate cancer.