文献类型：期刊文献

英文题名：Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China

作者：Chen, Lulu[1,2];Zhao, Yaqin[1,2];Sun, Jianhao[2,3];Jiao, Xinjuan[1];Wu, Zhenzhen[1,2];Wang, Jian[2];Qiu, Jie[2];Mao, Baohong[1,2];Liu, Qing[1,2]

第一作者：陈琳琳;Chen, Lulu

通信作者：Mao, BH[1];Liu, Q[1];Mao, BH[2];Liu, Q[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China;[3]Yangzhou Univ, Clin Med Coll, Yangzhou, Jiangsu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN PEDIATRICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001405637000001)】；

基金：The author(s) declare that this work was supported in part by the Gansu Provincial Science and Technology Department Grant (No.22JR5RA633), the Science and Technology Department Grant of Lanzhou City (Nos.2021-1-85 and 2022-5-85), the Natural Science Foundation of Gansu Province (Grant No.22JR11RA179), and the General Project of the Joint Scientific Research Fund supported by the Science and Technology Department of Gansu Province (Grant No.24JRRA935).

语种：英文

外文关键词：congenital heart defects; heavy metals; combined exposure; pregnancy; maternal blood

摘要：Background Previous research has demonstrated that exposure to individual heavy metals elevates the incidence rate of congenital heart defects (CHDs). However, there is a paucity of data concerning the relationship between combined exposure to multiple heavy metals and the occurrence of CHDs. This study seeks to investigate the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring in Lanzhou, China. Methods We conducted a comprehensive review of the birth cohort study undertaken at our hospital from 2010 to 2012, with the objective of investigating the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring. This analysis was performed utilizing a multifactorial conditional logistic regression model. Result A nested case-control study was conducted involving 97 case groups and 194 control groups. The median concentrations of nickel (Ni), barium (Ba), lead (Pb), and titanium (Ti) in the blood of pregnant women were measured at 25.58 mu g/L, 84.38 mu g/L, 69.67 mu g/L, and 304.65 mu g/L, respectively. The research identified a significant correlation between the concentrations of Ni, Pb, and Ti in the blood of pregnant women and the risk of CHDs (P < 0.05). The optimal cut-off for heavy metals in pregnant women's blood was determined using the ROC curve. Levels below this threshold indicated low exposure, while levels at or above it indicated high exposure. In comparison to low exposure levels, high exposure to nickel (>= 189.29 mu g/L) in pregnant women was associated with a 2.098-fold increase in the risk of CHDs in their offspring (OR = 3.098, 95% CI: 1.322-7.260). Similarly, high lead exposure (>= 86.70 mu g/L) resulted in a 1.192-fold increase in the risk of CHDs in offspring (OR = 2.192, 95% CI: 1.021-4.707). Furthermore, high exposure to titanium (>= 404.22 mu g/L) was linked to a 3.065-fold increase in the risk of CHDs in offspring (OR = 4.065, 95% CI: 1.887-8.758). When compared to low exposure levels, the combined exposure to four heavy metals in the blood of pregnant women is linked to a 4.946-fold increased risk of CHDs in their offspring (OR= 5.946, 95% CI: 2.872-12.309). A significant correlation was observed between Ti exposure levels and the combined exposure levels of four heavy metals in pregnant women, with respect to the risk of isolated CHDs and multiple CHDs (P < 0.05). Additionally, high Ni exposure levels in pregnant women are associated with an increased risk of multiple CHDs (OR 4.321, 95% CI: 1.646-11.348). Conclusion The cumulative exposure levels of Ni, Ba, Pb, and Ti in the blood of pregnant women are correlated with an elevated risk of CHDs in their offspring.