文献类型：期刊文献

英文题名：Network pharmacology and molecular docking reveal potential mechanisms of ginseng in the treatment of diabetes mellitus-induced erectile dysfunction and asthenospermia

作者：Liu, Liming[1,2];Zhang, Yuanfeng[3,4];Yang, Jiashu[2];Chen, Wenfang[5];Lan, Kaijian[4];Shi, Yibo[3];Zhang, Xiaogang[6];Xing, Xiping[7]

第一作者：Liu, Liming

通信作者：Xing, XP[1]

机构：[1]Xian Hosp Tradit Chinese Med, Dept Androl, Xian, Peoples R China;[2]Gansu Univ Chinese Med, Sch Integrated Chinese & Western Med, Lanzhou, Peoples R China;[3]Lanzhou Univ, Hosp 2, Clin Ctr Gansu Prov Nephron Urol, Key Lab Urol Dis Gansu Prov,Dept Urol, R China, Lanzhou, Peoples R China;[4]Shantou Cent Hosp, Dept Urol, Shantou, Peoples R China;[5]Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;[6]Gansu Med Coll, Affiliated Hosp, Dept Gastroenterol, Pingliang, Peoples R China;[7]Gansu Univ Chinese Med, Affiliated Hosp, Dept Urol & Androl, Lanzhou 730020, Gansu, Peoples R China

第一机构：Xian Hosp Tradit Chinese Med, Dept Androl, Xian, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：103

期号：34

起止页码：e39384

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85202157388);WOS:【SCI-EXPANDED(收录号:WOS:001298069900021)】；

基金：This study was supported by Gansu Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Chronic Diseases Open Fund (Grant No. GSMBKY2015-13); Natural Science Foundation of Gansu Province (Grant No. 23JRRA1198); Guidance Plan for Science and Technology Development Projects in Lanzhou City (Grant No. 2023-ZD-102); Intra-Hospital Project of the Affiliated Hospital of Gansu University of Chinese Medicine (Grant No. gzfy-2019-07); The Medical Science and Technology Program of Shantou (Grant No. 2021-3-44).

语种：英文

外文关键词：asthenospermia; diabetes mellitus; erectile dysfunction; network pharmacology; treating different diseases with the same treatment

摘要：Diabetes mellitus (DM) is a chronic metabolic disease that predisposes to chronic damage and dysfunction of various organs, including leading to erectile dysfunction (ED) and asthenospermia. Literature suggests that ginseng plays an important role in the treatment and management of DM. Ginseng may have a therapeutic effect on the complications of DM-induced ED and asthenospermia. The study aimed to explore the mechanisms of ginseng in the treatment of DM-induced ED and asthenospermia following the Traditional Chinese Medicine (TCM) theory of "treating different diseases with the same treatment." This study used network pharmacology and molecular docking to examine the potential targets and pharmacological mechanism of Ginseng for the treatment of DM-induced ED and asthenospermia. The chemical ingredients and targets of ginseng were acquired using the Traditional Chinese Medicine Systems Pharmacology database and analysis platform. The targets of DM, ED, and asthenospermia were extracted with the GeneCards and Online Mendelian Inheritance in Man databases. A protein-protein interaction network analysis was constructed. The Metascape platform was applied for analyzing the gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways. AutoDock Vina was used to perform molecular docking. Network pharmacology revealed that the main active components of the target of action were kaempferol, beta-sitosterol, ginsenoside rh2, stigmasterol, and fumarine. Core targets of the protein-protein interaction network included TNF, IL-1 beta, AKT1, PTGS2, BCL2, and JUN. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that they were mainly involved in AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, Lipid and atherosclerosis. The interactions of core active components and targets were analyzed by molecular docking. Ginseng may play a comprehensive therapeutic role in the treatment of DM-induced ED and asthenospermia through "multicomponent, multi-target, and multi-pathway" biological mechanisms such as inflammation and oxidative stress.