文献类型：期刊文献

英文题名：Sex differences in Helicobacter pylori infection and recurrence rate among 81,754 Chinese adults: a cross-sectional study

作者：Qiao, Yuqin[1];Zhou, Yun[1,2];Zhao, Li[3];Yang, Shengyi[4];Zhang, Xiaodong[5];Liu, Shixiong[1,2]

第一作者：Qiao, Yuqin

通信作者：Liu, SX[1];Liu, SX[2]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]First Hosp Lanzhou Univ, Dept Geriatr, Lanzhou 730000, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Med Ultrasound, Affiliated Hosp, Lanzhou 730020, Peoples R China;[4]Tianshui Combine Tradit Chinese & Western Med Hosp, Intens Care Unit, Tianshui 741020, Peoples R China;[5]ZhangYe Second Peoples Hosp, Intens Care Unit, Zhangye 734000, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]corresponding author), First Hosp Lanzhou Univ, Dept Geriatr, Lanzhou 730000, Peoples R China.

年份：2024

卷号：24

期号：1

外文期刊名：BMC GASTROENTEROLOGY

收录：;Scopus(收录号：2-s2.0-85203518773);WOS:【SCI-EXPANDED(收录号:WOS:001310605500004)】；

基金：All authors contributed to the writing of the paper. The authors appreciate everyone for their support and research assistance.

语种：英文

外文关键词：Helicobacter pylori; Sex differences; Age

摘要：Objective To compare the sex differences of Helicobacter pylori (HP) infection rate and 1-year recurrence rate. Methods A cross-sectional study was conducted on the prevalence of HP infection in 81,754 people who underwent physical examination in physical examination centers and outpatient clinics of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine, the Second People's Hospital of Zhangye City, Tianshui City Hospital of Integrated Chinese and Western Medicine, the First and Second Department of The First Hospital of Lanzhou University Physical Examination Center, from March 2010 to December 2019. Among them, 53,771 (65.77%) were males (18-91 years old) and 27,983 (34.23%) were females (18-94 years old). According to age, they were divided into young group, middle-aged group and old group. 1448 asymptomatic infected patients were selected and treated with bismuth-containing quadruple drug eradication therapy for 2 weeks. The eradication rate and recurrence rate after 1 year were compared between males and females. Results The overall infection rate was 49.59%, including 49.74% in males and 49.3% in females. The risk of infection in young women was lower than that in men (OR = 0.908, 95%CI: 0.868-0.95, P < 0.01), the risk of infection in older women was higher than that in men (OR = 1.137, 95%CI: 1.041-1.243, P < 0.01). The female infection rate was positively correlated with age from 18 to 60, and Spearman's correlation coefficient was 0.825 (P < 0.01). The overall eradication rate was 84.67% in intention-to-treat analysis (ITT) and 88.46% in protocol analysis (PP). The eradication rates of ITT and PP in the older group were 78.38% and 82.27%, respectively, which were lower than 87.25% and 89.39% in the male group (P < 0.05). The 1-year overall recurrence rate was 3.86%, including 2.82% in males and 5.44% in females (P < 0.05), female was a risk factor for recurrence after eradication after controlling for age (OR = 2.177, 95%CI 1.166-4.066, P < 0.05). There were no obvious adverse reactions during the treatment. Conclusion There is a positive linear correlation between HP infection rate and age increase in women. Older women have the characteristics of high HP infection rate, low eradication rate and high recurrence rate.