文献类型：期刊文献

英文题名：Elucidating the preventive and therapeutic effects of cardiac telocytes paracrine microRNAs on ischemic heart disease

作者：Jiang, Hugang[1];Tang, Yan[1];Liu, Ai[1];Ren, Chunzhen[1];Lin, Wenyan[2];Liu, Kai[1];Zhao, Xinke[3];Li, Yingdong[1]

第一作者：Jiang, Hugang

通信作者：Li, YD[1];Zhao, XK[2]

机构：[1]Gansu Univ Chinese Med, Dept Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Peoples Hosp, Daytime Diag & Treatment Ctr, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Cardiovasc Clin Med Ctr, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Cardiovasc Clin Med Ctr, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001466753900001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. This work was supported by grants from the National Natural Science Foundation Project(No. 82374279, No. 82360926), Natural Science Foundation of Gansu Province (No. 23JRRA1217), Gansu University of Traditional Chinese Medicine Science Research and Innovation Fund (2021KCYB-5), Major Science and Technology Projects in Gansu Province (No. 20ZD7FA002), Education Ranking and Leading Project of Gansu Province (No. 2021jyjbgs-03).

语种：英文

外文关键词：cardiac telocytes; paracrine secretions; endothelial cells; crosstalk mechanism; IHD

摘要：Telocytes (TCs), a newly identified type of mesenchymal cell since 2010, possess substantial potential in maintaining tissue homeostasis, orchestrating organ development, and facilitating tissue regeneration. Their distribution in blood, the adventitia of blood vessels, and the intima implies a close association with vascular function. Ischemic heart disease (IHD), a significant challenge in cardiovascular disease, is characterized by the occlusion of major vessels, obstruction of collateral circulation, and disruption of the capillary network-pathological features closely linked to endothelial cell damage. Myocardial tissue is rich in cardiac telocytes (cTCs), which, following myocardial injury, can secrete numerous miRNAs that promote angiogenesis, including miR-let-7e, miR-10a, and miR-126-3p. This indicates that cTCs may have therapeutic potential for IHD. The primary mechanism by which cTCs-derived exosomes exert paracrine effects is through reducing endothelial cell injury, suggesting that enhancing the production of cTCs could offer a novel therapeutic approach for treating IHD.